Immune Microenvironment in Colorectal Cancer: A New Hallmark to Change Old Paradigms

Table 2

Studies of tumor-infiltrating immune cells (Cytotoxic T CD8+ cells and CD45RO+) and prognosis in colorectal carcinoma.

Study	n	Immune cells	Findings: correlation with prognosis
Naito et al. [4]	131	CD8+ and GrB+ tumor-infiltrating cells.	Positive correlation for CD8+ T-cells
Jass et al. [20]	104	Tumor-infiltrating S-100+, HLA class II+, CD208+, CD1a+ dendritic cells.	Negative correlation for dendritic cells
Chiba et al. [38]	371	CD8+ T-cells within cancer cell nests	Positive correlation for CD8+ T-cells
Galon et al. [39]	490	CD3+, CD8+, GrB+, and CD45RO+ lymphoid infiltrates in tumors/invasive margin	Positive correlation for CD8+ and CD45RO+ T-cell
Pagès et al. [40]	490	CD3+, CD8+, GrB+, and CD45RO+ lymphoid infiltrates in tumors/invasive margin	Positive correlation for CD45RO+ T-cells
Camus et al. [36]	142	CD3+, CD5+, CD8+, CCR+, CD1a+, Ki67+, CD68+, FOXP3+, and cytoDEATH+ tumor-infiltrating cells	Positive correlation for CD8+ and CD45RO+ T-cells
Guidoboni et al. [41]	109	CD3+, CD8+, and GrB+ tumor-infiltrating cells	Positive correlation for CD8+ T-cells
Menon et al. [23]	93	CD4+, CD8+, CD56+, and CD57+ intraepithelial cells.	Positive correlation for CD8+ and CD57+ cells
Diederichsen et al. [37]	41	CD3+, CD8+, and CD4+ tumor-infiltrating cells	Positive for CD8+ T-cells, negative for CD4+ T-cells
Ogino et al. [42]	843	Lymphocytes on top of tumor cells	Positive correlation for lymphocytes
Ropponen et al. [21]	276	Lymphocytic infiltration in the center and periphery of tumors	Positive correlation for lymphocytes