Clinical Characteristics of Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome in North Indian Population of HIV/AIDS Patients Receiving HAART

Table 4

Diagnosis of paradoxical TB-IRIS according to consensus case-definition.

Sl. no.	TB		TB-IRIS	Clinical criteria*
	Site	Category		Major	Minor
(1)	DTB (Lung + Pleura + mediastinal LN)	Probable	DTB (Lung + Pleura + mediastinal + RP/mesenteric LN)	New LN	Worsening constitutional symptoms (fever, weight loss, etc.)
(2)	LNTB (cervical)	Definitive	DTB (cervical + mediastinal + RP/mesenteric LN)	New LN	Worsening constitutional symptoms
(3)	LNTB (cervical)	Probable	DTB (cervical + mediastinal + RP/mesenteric LN)	New LN	Worsening constitutional symptoms
(4)	PTB	Definitive	PTB	Worsening CXR	Worsening constitutional symptoms; Worsening respiratory symptoms (cough, dyspnoea, etc.)
(5)	LNTB (cervical)	Probable	LNTB (cervical)	New & enlarging LN	Worsening constitutional symptoms

PTB: pulmonary tuberculosis; RP: retroperitoneal; LN: lymph nodes; DTB: disseminated tuberculosis
*“Antecedent requirements” and “Alternative explanations for clinical deterioration” criteria were fulfilled in all the cases.