Clinical Characteristics of Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome in North Indian Population of HIV/AIDS Patients Receiving HAART

Table 8

Description of TB in patients with TB-IRIS (at the time of IRIS) and ART-associated TB.

	Paradoxical TB-IRIS (𝑛=5)*	ART-associated TB (𝑛=6)
PTB [𝑛(%)]	1	5
EPTB [𝑛(%)]	4	1
DTB [𝑛(%)]	3	—
Lung + Pleura + mediastinal LN + RP/mesenteric LN [𝑛(%)]	1	—
Cervical LN + mediastinal LN + RP/mesenteric LN [𝑛(%)]	2	—
Lymph node [𝑛(%)]	1	1
Cervical [𝑛(%)]	1	1

PTB: pulmonary tuberculosis; EPTB: extrapulmonary tuberculosis; DTB: disseminated tuberculosis; LN: lymph node
EPTB, types of EPTB and subtypes of EPTB types presented in absolute no. of cases
*Three of the 5 patients with paradoxical IRIS had cervical TB lymphadenopathy at presentation while one had disseminated and the other had pulmonary TB. After being started on ART, one with cervical TB lymphadenopathy developed enlargement of the previously existing lymph nodes along with appearance of new nodes in the neck; other two with cervical TB lymphadenopathy developed disseminated TB; in one with disseminated TB (lung, pleura and mediastinum) the disease became more extensive (with abdominal involvement); and one with pulmonary TB developed new chest infiltrates with increased bacillary load in the sputum.