Dendritic Cell-Based Vaccines Positively Impact Natural Killer and Regulatory T Cells in Hepatocellular Carcinoma Patients

Figure 5

Treg cell responses to DC coculture. HD (a) and HCC patient (b, c, and d) CD4⁺ T cells were cocultured with differentially treated DC. The FOXP3 expression in CD3⁺/CD4⁺/CD25^hi cells is shown in (a) as MFI (left), percent positive (middle). The right group is the frequency of total activated (CD25⁺) CD4⁺ T cells. The FOXP3 MFI in Treg in HCC patients is shown in (b). The percent CD3⁺/CD4⁺/CD25^hi/FOXP3⁺ Treg in HCC patients is shown in (c). The overall frequency of activated CD4⁺ T cells is shown in (d) (% CD3⁺/CD4⁺/CD25⁺ cells).