Innate Immune Effectors in Mycobacterial Infection
Figure 3
TLR-dependent innate response to mycobacteria. Several TLR-dependent gene products mediate innate immune responses to mycobacteria. Mycobacterial stimulation of TLR2 induces expression of Cyp27b1 and vitamin D receptor (VDR), both of which are involved in vitamin D3-dependent induction of cathelicidin which directly kills mycobacteria. TLR-dependent induction of SLPI mediates disruption of the mycobacterial cell wall. Lcn2, which is also induced by TLR stimulation, is internalized into the alveolar epithelial cells and inhibits mycobacterial growth by sequestering iron uptake.
