Interferon Lambda: A New Sword in Cancer Immunotherapy

Figure 2

Cellular targets for type I and type III IFNs. Response to IFN-α and IFN-λ in cells from different origins in human. The IFN response was assessed by measuring the IFN-induced cell signaling (Stat activation) and cell activity (MHC class I antigen stimulation). In contrast to IFN-α, only restricted cells respond to IFN-λ, including epithelial-like cells, forming the major organs of the body.