Involvement of Indoleamine 2,3-Dioxygenase in Impairing Tumor-Infiltrating CD8⁺ T-Cell Functions in Esophageal Squamous Cell Carcinoma

Figure 3

Overall survival curves drawn using Kaplan-Meier method according to the IDO expression, the number of intraepithelial CD8⁺ TILs and the number of stromal CD8⁺ TILs in 135 ESCC patients. (a) There was a significant difference in the overall survival between patients with low IDO expression (bold lines) and high IDO expression (dotted lines). (b) Significant differences in overall survival between the high intraepithelial CD8⁺ TIL groups (≥10) and the low intraepithelial CD8⁺ TIL groups (<10). (c) Significant differences in overall survival between the high stromal CD8⁺ TIL groups (≥20) and the low stromal CD8⁺ TIL groups (<20).

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