Research Article
Involvement of Indoleamine 2,3-Dioxygenase in Impairing Tumor-Infiltrating CD8+ T-Cell Functions in Esophageal Squamous Cell Carcinoma
Table 1
Characteristics of 135 patients with esophageal squamous cell carcinoma and correlation between the clinicopathologic features and expression of IDO.
| Characteristics | All cases (n) | IDO low n ( %) | IDO high n ( %) | Significance (P)* |
| Gender | | | | | Male | 100 | 45 (45.0) | 55 (55.0) | 0.069 | Female | 35 | 22 (62.9) | 13 (37.1) | | Age (y) | | | | | <60 | 80 | 35 (43.8) | 45 (56.2) | 0.100 | ≥60 | 55 | 32 (58.2) | 23 (41.8) | | Stage | | | | | I-II | 74 | 45 (60.8) | 29 (39.2) | 0.004 | III-IV | 61 | 22 (36.1) | 39 (63.9) | | Histological differentiation | | | | | Well | 41 | 25 (61.0) | 16 (39.0) | 0.075 | Moderate | 57 | 22 (38.6) | 35 (61.4) | | Poor | 37 | 20 (54.1) | 17 (45.9) | | Tumor diameter | | | | | <40mm | 54 | 25 (46.3) | 29 (53.7) | 0.527 | ≥40mm | 81 | 42 (51.9) | 39 (48.1) | | Depth of invasion | | | | | Submucosa | 7 | 5 (71.4) | 2 (28.6) | 0.300 | Muscularis propria | 46 | 25 (54.3) | 21 (45.7) | | Adventitia | 82 | 37 (45.1) | 45 (54.9) | | pT classification | | | | | T1-T2 | 44 | 28 (63.6) | 16 (36.4) | 0.024 | T3-T4 | 91 | 39 (42.9) | 52 (57.1) | | pN classification | | | | | Yes | 65 | 25 (38.5) | 40 (61.5) | 0.012 | No | 70 | 42 (60.0) | 28 (40.0) | | P metastasis | | | | | Yes | 9 | 4 (44.4) | 5 (55.6) | 0.982 | No | 126 | 63 (50.0) | 63 (50.0) | | Intraepithelial CD8+ | | | | | High (≥10) | 62 | 38 (61.3) | 24 (38.7) | 0.013 | Low (<10) | 73 | 29 (39.7) | 44 (60.3) | | Stromal CD8+ | | | | | High (≥20) | 66 | 42 (63.6) | 24 (36.4) | 0.001 | Low (<20) | 69 | 25 (36.2) | 44 (63.8) | |
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