Anti-IL-6 Receptor Antibody Causes Less Promotion of Tuberculosis Infection than Anti-TNF-𝛼 Antibody in Mice

Figure 6

Survival and TB CFU in spleen, lungs, and liver of TB-challenged IL-6 KO, TNFR1 KO, and WT DBA/1 mice. (a) Survival of TB-infected IL-6 KO mice (𝑛=5), TNFR1 KO mice (𝑛=3), and WT DBA/1 control mice (𝑛=10). IL-6 KO mice versus TNFR1 KO mice (𝑃<.01, Kaplan-Meyer analysis). (b) TB CFU in lungs, spleen, and liver 4 weeks after infection in IL-6 KO mice (𝑛=4), TNFR1 KO mice (𝑛=2), and WT DBA/1 control mice (𝑛=10). Results are expressed as the mean ± S.E.M. For TNFR1 KO mice, individual values are shown. N.S.: Not significant by Student’s 𝑡-test.

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