Review Article
T Cell Recognition of Autoantigens in Human Type 1 Diabetes: Clinical Perspectives
Table 3
CD8+ T-cell epitopes on human preproinsulin.
| Epitope preproinsulin | Epitope Insulin nomenclature | MHC restriction | responders | references |
| PPI2-10 | L2-10 | HLA-A*0201 | Recent-onset T1D | [96] | PPI2-11 | L2-11 | HLA-A*0201 | Recent-onset T1D | [56] | PPI2-11 | L2-11 | HLA-A24 | Recent-onset T1D | [56] | PPI2-11 | L2-11 | HLA-B8 | Recent-onset T1D | [56] | PPI6-14/PPI6-16 | L6-14/L6-16 | HLA-A*0201 | Recent-onset T1D | [56] | PPI14-23 | L14-23 | HLA-A*0201 | Recent-onset T1D | [56] | PPI15-25 | L14-B1 | HLA-A*0201 | Recent-onset T1D | [56] | PPI15-24 | L15–L24 | HLA-A*0201 | Recent-onset T1D | [57] | PPI15-25 | L14-B1 | HLA-A*0201 | Transgenic mice | [54] | PPI23-42 | L23-18 | HLA-A24 | Recent-onset T1D | [56] | PPI34-42 | B10-18 | HLA-A*0201 | Recent-onset T1D | [54, 55, 58] | Islet graft rejection | Transgenic mice | PPI38-46 | B14-22 | HLA-A3 | Recent-onset T1D | [55] | PPI38-46 | B14-22 | HLA-A11 | Recent-onset T1D | [55] | PPI39-47 | B15-23 | HLA-A24 | Recent-onset T1D | [141] | PPI39-48 | B15-24 | HLA-A24 | Recent-onset T1D | [55] | PPI41-50 | B17-26 | HLA-A1 | Recent-onset T1D | [55] | PPI41-50 | B17-26 | HLA-A3 | Recent-onset T1D | [55] | PPI41-50 | B17-26 | HLA-A11 | Recent-onset T1D | [55] | PPI42-51 | B18-27 | HLA-A1 | Recent-onset T1D | [54, 55] | Transgenic mice | PPI42-51 | B18-27 | HLA-A*0201 | Recent-onset T1D | [55] | PPI42-51 | B18-27 | HLA-B8 | Recent-onset T1D | [55] | PPI42-51 | B18-27 | HLA-B18 | Recent-onset T1D | [55] | PPI44-51 | B20-27 | HLA-A1 | Recent-onset T1D | [55] | PPI44-51 | B20-27 | HLA-B8 | Recent-onset T1D | [55] | PPI45-53 | B21-29 | HLA-A3 | Recent-onset T1D | [55] | PPI49-57 | B25-C1 | HLA-B8 | Recent-onset T1D | [55] | PPI51-61 | B27-C 5 | HLA-B8 | Recent-onset T1D | [55] | PPI76-84 | C20-28 | HLA-A*0201 | Transgenic mice | [54, 96] | Recent-onset T1D | PPI83-89 | C27-C(34) | HLA-A*0201 | Transgenic mice | [54] | PPI85-94 | C29-A5 | HLA-A*0201 | Transgenic mice | [54, 96] | Recent-onset T1D | PPI90-99 | A1-10 | HLA-A*0201 | Transgenic mice | [54] | PPI101-109 | A12-20 | HLA-A*0201 | Transgenic mice | [54, 96] | Recent-onset T1D |
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