Review Article

T Cell Recognition of Autoantigens in Human Type 1 Diabetes: Clinical Perspectives

Table 3

CD8+ T-cell epitopes on human preproinsulin.

Epitope preproinsulinEpitope Insulin nomenclatureMHC restrictionrespondersreferences

PPI2-10L2-10HLA-A*0201Recent-onset T1D[96]
PPI2-11L2-11HLA-A*0201Recent-onset T1D[56]
PPI2-11L2-11HLA-A24Recent-onset T1D[56]
PPI2-11L2-11HLA-B8Recent-onset T1D[56]
PPI6-14/PPI6-16L6-14/L6-16HLA-A*0201Recent-onset T1D[56]
PPI14-23L14-23HLA-A*0201Recent-onset T1D[56]
PPI15-25L14-B1HLA-A*0201Recent-onset T1D[56]
PPI15-24L15–L24HLA-A*0201Recent-onset T1D[57]
PPI15-25L14-B1HLA-A*0201Transgenic mice[54]
PPI23-42L23-18HLA-A24Recent-onset T1D[56]
PPI34-42B10-18HLA-A*0201Recent-onset T1D[54, 55, 58]
Islet graft rejection
Transgenic mice
PPI38-46B14-22HLA-A3Recent-onset T1D[55]
PPI38-46B14-22HLA-A11Recent-onset T1D[55]
PPI39-47B15-23HLA-A24Recent-onset T1D[141]
PPI39-48B15-24HLA-A24Recent-onset T1D[55]
PPI41-50B17-26HLA-A1Recent-onset T1D[55]
PPI41-50B17-26HLA-A3Recent-onset T1D[55]
PPI41-50B17-26HLA-A11Recent-onset T1D[55]
PPI42-51B18-27HLA-A1Recent-onset T1D[54, 55]
Transgenic mice
PPI42-51B18-27HLA-A*0201Recent-onset T1D[55]
PPI42-51B18-27HLA-B8Recent-onset T1D[55]
PPI42-51B18-27HLA-B18Recent-onset T1D[55]
PPI44-51B20-27HLA-A1Recent-onset T1D[55]
PPI44-51B20-27HLA-B8Recent-onset T1D[55]
PPI45-53B21-29HLA-A3Recent-onset T1D[55]
PPI49-57B25-C1HLA-B8Recent-onset T1D[55]
PPI51-61B27-C 5HLA-B8Recent-onset T1D[55]
PPI76-84C20-28HLA-A*0201Transgenic mice[54, 96]
Recent-onset T1D
PPI83-89C27-C(34)HLA-A*0201Transgenic mice[54]
PPI85-94C29-A5HLA-A*0201Transgenic mice[54, 96]
Recent-onset T1D
PPI90-99A1-10HLA-A*0201Transgenic mice[54]
PPI101-109A12-20HLA-A*0201Transgenic mice[54, 96]
Recent-onset T1D