Review Article
T Cell Recognition of Autoantigens in Human Type 1 Diabetes: Clinical Perspectives
Table 4
CD8+ T-cell epitopes of human T1D autoantigens (other than preproinsulin).
| Epitope preproinsulin | MHC restriction | responders | references |
| GAD114-123 | HLA-A*0201 | Recent-onset T1D | [38, 96, 103] | Transgenic mice | GAD114-122 | HLA-A*0201 | Recent-onset T1D | [101] | GAD110-118 | HLA-A*0201 | Transgenic mice | [103] | GAD159-167 | HLA-A*0201 | Transgenic mice | [103] | GAD476-484 | HLA-A*0201 | Transgenic mice | [103] | GAD536-545 | HLA-A*0201 | Transgenic mice | [103] | IAPP5-13 | HLA-A*0201 | Recent-onset T1D | [98] | IAPP9-17 | HLA-A*0201 | At risk | [99, 100] | Recent-onset T1D | T1D | IGRP215-223 | HLA-A*0201 | Recent-onset T1D | [100] | IGRP152-160 | HLA-A*0201 | At risk | [99, 100] | T1D | IGRP228-236 | HLA-A*0201 | Transgenic mice | [96, 102] | Recent-onset T1D | IGRP266-273 | HLA-A*0201 | Transgenic mice | [96, 102] | Recent-onset T1D | IGRP206-214 | HLA-A*0201 | Transgenic mice | [102] | IGRP337-345 | HLA-A*0201 | Transgenic mice | [102] | IGRP265-273 | HLA-A*0201 | Transgenic mice | [102] | GFAP143-151 | HLA-A*0201 | At risk | [99] | T1D | GFAP214-222 | HLA-A*0201 | At risk | [99] | T1D | IA-2797-805 | | Normal subjects | [97] | | Recent-onset T1D | IA-2172-180 | HLA-A*0201 | Recent-onset T1D | [100] | IA-2482-490 | HLA-A*0201 | Recent-onset T1D | [100] | IA2790-798 | HLA-A*0201 | Transgenic mice | [103] | IA2805-813 | HLA-A*0201 | Transgenic mice | [103] | IA2830-839 | HLA-A*0201 | Transgenic mice | [103] | IA2962-970 | HLA-A*0201 | Transgenic mice | [103] |
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