Immunogenicity and Protective Efficacy against Murine Tuberculosis of a Prime-Boost Regimen with BCG and a DNA Vaccine Expressing ESAT-6 and Ag85A Fusion Protein
Figure 8
Representative lung pathology of C57BL/6 mice after challenge. Vaccinated C57BL/6 mice were challenged i.v with 106 CFU virulent Mycobacterium tuberculosis H37Rv strain. Four weeks after infection, lung tissue sections from different vaccine groups were prepared for HE staining (amplification 10 × 4), (a) control; (b) vector control; (c) pcD685A; (d) BCG; (e) BCG plus vector; (f) BCG plus pcD685A.
