The Therapeutic Effect of Cytokine-Induced Killer Cells on Pancreatic Cancer Enhanced by Dendritic Cells Pulsed with K-Ras Mutant Peptide
Figure 1
The morphological changes of k-ras pulsed DC and K-ras-DCCIK under scanning and transmission electron microscopy (experiment 2.5). DCs pulsed with K-ras mutant peptide show a larger soma, and plenty of dendritic bulges on their surfaces (Figure 1(a)). Under transmission electron microscopy, DCs show irregular-shape, large, and long dendritic bulges on their surfaces. In the DCs, organelles are abundant, and many mitochondria and rough endoplasmic reticulum can be seen, but less lysosome are present (Figure 1(b)). Coculture of DCs and CIKs for 14 days; under scanning electron microscopy, cells aggregated together to form many cell masses, on the surfaces of which there were plenty of dendritic bulges (Figure 1(c)).
