The Therapeutic Effect of Cytokine-Induced Killer Cells on Pancreatic Cancer Enhanced by Dendritic Cells Pulsed with K-Ras Mutant Peptide
Figure 8
Survival of nude mice inoculated subcutaneously in the back with PANC-1 (K-ras+) and SW1990(K-rasā) cells after immunotherapy with CTLs and different CIKs (experiment 2.8) concerning the effects on the survival time of PANC-1 (K-ras+) tumor-bearing mice (Figure 8(a)), the survival time of group K-ras-DCCIK was prolonged remarkably, compared with other groups (). No statistical difference was found among the group DCCIK, CIK and CTL (). It is demonstrated that the k-ras-DC induced CTL can inhibit PANC-1. Meanwhile, K-ras-DCCIK can produce specific and immediate killing effect on PANC-1. Concerning the effects on the survival time of SW1900 (K-rasā) tumor-bearing mice (Figure 8(b)), the survival time of group K-ras-DCCIK, DCCIK and CIK was elongated dramatically. Compared with group CTL (). The CIK groups possess the direct inhibition to SW1900. The CTL induced by K-ras-DC showed the lower inhibition to K-ras mutation negative cell, SW1900. Thus, the survival time of the SW1900 tumor-bearing mice was not extended.
