The M. tuberculosis Phosphate-Binding Lipoproteins PstS1 and PstS3 Induce Th1 and Th17 Responses That Are Not Associated with Protection against M. tuberculosis Infection

Figure 5

Effects of PstS1- or PstS3-immunizations on protection against M. tuberculosis challenge in mice. Mice (5 mice/group) were immunized with PstS1 or PstS3 antigens according to Figure 1, and challenged with M. tuberculosis H37Rv. Four weeks after infection, the bacteria in the lung were enumerated as described in Materials and Methods. Data are expressed as mean of the five individual mice ± SE. The level of statistical significance for differences between test groups and the control unvaccinated mice were determined by ANOVA test (*significant).