Table 1: Cytokine- and chemokine-expressing rBCG strains.

StrainCytokineSpeciesImmunological effectReference

IL-2 BCG (RBD)IL-2mTh1 cyt prod, Antitumor, Cytotoxicity[30, 100, 101]
IL-2 BCG (MAO)IL-2rTh1 cyt prod[100]
BCG-CIIL-2hAnti-BCG[102]
BCG-CIIIL-2hAnti-BCG[102]
BCG-IL-2IL-2mCI, Th1 & Th2 cyt prod[103]
BCG-GM-CSFGM-CSFmCI, Th1 & Th2 cyt prod, DC act, Anti-M.tb [103, 104]
BCG-IFN-γIFN-γmCI, Th1 & Th2 cyt prod, Anti-BCG[103, 105]
rBCG/IL-2IL-2mCI, Th1 cyt prod, Anti-BCG[106108]
rBCG-IL-2/GFPIL-2mCI, Th1 cyt prod, Anti-BCG[109]
rBCG (α-Ag-IL-2)IL-2mTh1 cyt prod, Cytotoxicity[28]
BCG-IFN-γIFN-γmTh1 cyt prod, Anti-BCG[110]
rBCG-IFN-αIFN-α 2BhTh1 cyt prod, Cytotoxicity[38, 111, 112]
rBCG/IL-18IL-18mno clear effect[108]
BCG IL-18IL-18mTh1 & Th2 cyt prod[113, 114]
BCG-hIL2MUC1IL-2hCI, Th1 cyt prod, Antitumor[95, 96]
rBCG-IFN-γIFN-γmCI, Th1 cyt prod, Antitumor[115]
rBCG-IL-18IL-18mTh1 cyt prod, Anti-BCG, Cytotoxicity[29, 30]
rBCG-huIL-2-ESAT6IL-2hCI, Th1 cyt prod, Cytotoxicity, HI[116]
rBCG-IL-2IL-2hTh1 cyt prod[112]
BCGMCP-3MCP-3mCI, Anti-BCG[117]
rBCG-AEIIFN-γmCI, HI, Anti-M.tb [118]
rBCG-Ag85B-IL15IL-15mCI, Th1 cyt prod, Anti-M.tb [119]
rBCG-MVNTR4-CSFGM-CSFhCI, Th1 cyt prod, Antitumor[97, 99]
rBCG-MVNTR8-CSFGM-CSFhCI, Th1 cyt prod, Antitumor[97, 99]
rBCG-Ag85B-Esat6-TNF-αTNF-αmCI, HI[120]

Anti-BCG: anti-BCG infection; Anti-M.tb: anti-Mycobacterium tuberculosis infection; CI: cellular immunity; DC act: dendritic cell activation; h: human; HI: humoral immunity; m: mouse; r: rat; Th1 cyt prod: T helper type 1 cytokine production; Th2 cyt prod: T helper type 2 cytokine production.