Comparative Approach to Define Increased Regulatory T Cells in Different Cancer Subtypes by Combined Assessment of CD127 and FOXP3

Table 3

Assessment of T_reg-cell frequencies in peripheral blood.

	Control	Colon		CLL		MGUS		MM
	Mean (SD)	Mean (SD)	𝑃	Mean (SD)	𝑃	Mean (SD)	𝑃	Mean (SD)	𝑃
CD4^+CD127^low	4.6 (1.3)	7.6 (1.5)	<0.001	8.3 (2.5)	<0.005	5.4 (1.3)	n.s.	11.2 (5.9)	<0.01
CD4^+CD127^lowFOXP3^+	4.1 (0.7)	7.2 (2.4)	<0.005	8.9 (4.0)	<0.005	6.0 (1.8)	<0.05	11.7 (5.4)	<0.005
CD4^+CD127^lowFOXP3^+CD25^high	2.5 (0.6)	4.3 (1.6)	<0.005	4.7 (2.7)	<0.05	3.9 (1.3)	<0.05	7.1 (4.9)	<0.05
CD4^+CD25^high	2.8 (0.9)	7.6 (1.2)	<0.001	6.4 (1.8)	<0.001	4.5 (1.1)	<0.05	9.0 (5.3)	<0.01
CD4^+CD25^highCD127^low	2.9 (0.9)	4.5 (1.2)	<0.005	4.5 (2.0)	<0.05	3.5 (1.3)	n.s.	7.0 (5.1)	<0.05
CD4^+CD25^highFOXP3^+	2.1 (0.8)	4.2 (1.2)	<0.001	3.6 (1.7)	<0.05	2.5 (0.6)	n.s.	6.3 (4.5)	<0.05
CD4^+FOXP3^+	2.8 (0.9)	4.7 (2.1)	<0.05	4.7 (2.4)	<0.05	3.6 (1.1)	n.s.	7.7 (5.1)	<0.05

Definition of subpopulations based on expression of CD25, CD127, and FOXP3 (SD: standard deviation, n.s.: not significant).