Clinical Study
Comparative Approach to Define Increased Regulatory T Cells in Different Cancer Subtypes by Combined Assessment of CD127 and FOXP3
Table 4
Assessment of Treg-cell frequencies in lymph node biopsies.
| | Control | FL | HD | | Mean (SD) | Mean (SD) | | Mean (SD) | |
| | CD4+ CD127low | 54.7 (23.1) | 68.6 (15.8) | >0.05 | 68.0 (12.7) | >0.05 | | CD4+ CD127lowFOXP3+ | 10.1 (4.4) | 21.8 (8.0) | <0.01 | 24.4 (13.1) | <0.05 | | CD4+ CD127lowFOXP3+ CD25high | 3.1 (1.9) | 11.7 (5.5) | <0.005 | 6.4 (2.3) | <0.05 | | CD4+ CD25high | 5.1 (2.9) | 13.8 (7.1) | <0.05 | 11.2 (3.3) | <0.005 | | CD4+ CD25highCD127low | 4.1 (3.0) | 16.3 (7.1) | <0.005 | 11.3 (5.2) | <0.05 | | CD4+ CD25highFOXP3+ | 2.9 (2.6) | 10.0 (5.4) | <0.01 | 5.6 (1.2) | <0.05 | | CD4+ FOXP3+ | 10.3 (5.5) | 19.4 (8.5) | <0.05 | 23.4 (12.0) | <0.05 |
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Definition of subpopulations based on expression of CD25, CD127, and FOXP3 (SD: standard deviation, n.s.: not significant).
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