Different Transcriptional Profiles of Human Monocyte-Derived Dendritic Cells Infected with Distinct Strains of Mycobacterium tuberculosis and Mycobacterium bovis Bacillus Calmette-Guérin
Table 3
(a) nDens of upregulated genes of DCs infected with different MTB and BCG strains. (b) nDens of downregulated genes of DCs infected with different MTB and BCG strains.
(a)
Gene
MTB H37Rv
MTB CMT97
BCG Aventis
BCG Japan
Uninfected DCs
ADAM19
0.3; 0.4; 1.5
0.3; 0.2; 1.8
0.2; 0.7; 0.1
0.3; 0.6; 1
0.2; 0.07; 0.5
CCL20
0.4; 1; 0.8
0.4; 2.5; 1.4
0.9; 2.3; 0.8
0.5; 0.8; 1.1
0.04; 0.001; 0.4
CCL22
8.5; 1.8; 11.1
6.9; 3.7; 12.4
4.3; 1.8; 12.1
8.1; 1.5; 9.8
0.3; 0.5; 0.2
CCR7
3.1; 0.001; 1.7
3.2, 0.9; 1.9
0.5; 1.8; 1.6
2.4; 0.9; 2.2
0.1; 0.2; 0.05
IL-1β
2.1; 2.9; 14.4
1.7; 10.5; 19.0
0.3; 6.5; 10.8
1.9; 4.8; 14
0.09; 0.9; 0.8
IL-6
0.5; 0.02; 2.9
0.1; 0.4; 3.4
0.001; 0.6; 2.3
0.1; 0.3; 3.2
0.01; 0.01; 0.1
IL-10
1.8; 3.7; 6.6
1.0; 1.2; 8.9
1.2; 1.3; 5.8
1.0; 0.9; 4
0.4; 0.3; 4.4
IL-12p40
0.6; 0.3; 0.9
0.6; 0.7; 0.7
0.7; 0.1; 1.0
0.4; 0.01; 1.5
0.1; 0.1; 0.004
SOD2
0.8; 1.6; 5.5
0.8; 3.4; 7.6
0.9; 1.5; 3.7
0.5; 1.5; 5.4
0.1; 0.7; 0.7
ADAR
0.4; 0.2; 0.2
0.2; 0.1; 0.1
0.3; 0.1; 0.1
0.4; 0.3; 0.2
0.2; 0.1; 0.1
CCL3
4.1; 7.0; 11.0
3.6; 6.5; 5.6
7.0; 4.6; 10.8
2.5; 3.7; 1.2
1.7; 3.4; 0.6
CCL19
0.1; 0.1; 0.001
0.3; 0.007; 0.001
0.2; 0.3; 0.4
0.2; 0.1; 0.5
0.001; 0.1; 0.001
CD80
3.3; 0.4; 0.2
3.2; 0.5; 0.2
3.9; 0.9; 0.2
5.8; 0.7; 0.9
2.1; 0.3; 0.2
CD86
0.3; 0.001; 0.1
0.2; 0.02; 0.4
0.1; 0.1; 0.4
0.2; 0.01; 0.4
0.05; 0.02; 0.2
CFLAR
0.4; 0.5; 0.3
0.5; 0.5; 0.3
1.1; 1.3; 0.2
0.8; 0.8; 0.4
0.5; 0.3; 0.2
CRF
0.3; 0.3; 0.001
0.3; 0.1; 0.01
1.1; 0.2; 0.001
0.1; 0.02; 0.001
0.3; 0.1; 0.001
EBI3
0.1; 0.2; 0.5
0.1; 0.001; 0.7
0.01; 0.001; 0.2
0.01; 0.001; 0.3
0.01; 0.001; 0.008
IL-1α
0.02; 0.01; 0.4
0.1; 0.6; 0.5
0.3; 0.6; 0.3
0.4; 0.3; 0.9
0.02; 0.01; 0.001
LAMP3
5.1; 24.0, 1.6
10.6; 31.3; 2.1
13.4; 12.9; 2.3
21.8; 26.0; 1.7
9.3; 11.8; 0.7
MT2A
0.2; 0.1; 11.1
0.4; 0.5; 11.5
0.4; 0.2; 7.1
0.08; 0.1; 8.4
0.2; 0.2; 0.1
PLAUR
0.06; 0.1; 1.5
0.1; 0.7; 0.7
0.2; 0.4; 1.2
0.06; 0.1; 1.2
0.1; 0.1; 0.1
TNFRSF6
0.6; 0.1; 0.001
0.7; 0.006; 0.004
1.6; 0.4; 0.001
1.4; 0.2; 0.001
0.6; 0.001; 0.001
(b)
Gene
MTB H37Rv
MTB CMT97
BCG Aventis
BCG Japan
Uninfected DCs
CD1A
0.1; 0.2; 0.001
0.1; 0.001; 0.02
0.06; 0.001; 0.05
0.2; 0.001; 0.001
5.2; 0.3; 1.1
CD1B
0.04; 0.4; 0.001
0.05; 0.001; 0.02
0.05; 0.001; 0.06
0.008; 0.001; 0.07
1.3; 0.001; 0.7
CD209
0.05, 0.1; 0.08
0.02; 0.03; 0.001
0.04; 0.001; 0.03
0.01; 0.2; 0.03
0.3; 0.1; 0.4
CSF1R
0.05; 0.4; 0.1
0.1; 0.5; 0.001
0.5; 0.2; 0.04
0.1; 0.1; 0.3
0.3; 0.2; 0.5
DCP1B
0.2; 0.001; 0.04
0.3; 0.001; 0.1
0.3; 0.1; 0.07
0.1; 0.07; 0.01
0.4; 0.1; 0.1
DCSTAMP
1.3; 0.001; 0.001
1.6; 0.001; 0.3
0.2; 0.05; 0.02
2.1; 0.01; 0.001
3.0; 0.1; 0.05
GBP3
0.3; 0.4; 0.1
0.08; 0.5; 0.03
0.1; 0.8; 0.05
0.1; 0.3; 0.04
0.1; 0.7; 0.1
GIP2
0.05; 0.001; 0.9
0.08; 0.3; 0.6
0.07; 0.4; 0.4
0.001; 0.1; 0.7
0.3; 0.3; 0.7
IL-18
0.1; 1.9; 0.2
0.1; 1.6; 0.2
1.1; 1.8; 0.2
0.1; 0.6; 0.2
0.2; 2.7; 0.2
PFN1
0.9; 0.5; 3.1
0.6; 0.4; 5.0
0.7; 0.6; 2.3
0.7; 0.2; 3.5
0.8; 0.5; 8.5
TLR6
0.05; 0.09; 0.001
0.08; 0.3; 0.03
0.1; 0.3; 0.001
0.001; 0.1; 0.001
1.4; 0.3; 0.02
RNA expression of infected and uninfected DCs of three independent experiments. Values are reported as nDens.
