Gender-Specific Cytokine Pathways, Targets, and Biomarkers for the Switch from Health to Adenoma and Colorectal Cancer

<table>Serum Th1 and Th2 network relationships. Significant gender common and gender-specific Th1/Th2 network relationships were found in serum which could be used as biomarkers to indicate the direction of T cell differentiation in the immune response. Positive relationship (+); negative relationship (−); resting (RC) and activation (AC) conditions; not significant (ns); Th1: IL2, IFN<i>γ</i>; Th2: IL4, IL6, IL10;  APC: TNF<i>α</i>, IL1<i>β</i>.</table>

Journal of Immunology Research

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Figure 5

Figure 5: Gender-Specific Cytokine Pathways, Targets, and Biomarkers for the Switch from Health to Adenoma and Colorectal Cancer 