Tumor and Microenvironment Modification during Progression of Murine Orthotopic Bladder Cancer

Table 4

Bladder gene expression at day 28 segregated by PSA expression.

	Day 28
Group	Control	Cured	Tumor (small)	Tumor (medium)	Tumor (large)
Gene/no	11	4	5	6	4
PSA	0.491 ± 0.532	0.095 ± 0.099	73.03 ± 69.92	311.2 ± 45.85	1602 ± 1914*
AGTR2	1.381 ± 0.623	1.072 ± 0.251	0.342 ± 0.249*	0.018 ± 0.011*	0.187 ± 0.130*
CSF2	2.621 ± 5.554	1.637 ± 0.443	18.16 ± 21.55	28.88 ± 12.69	76.86 ± 52.56*
CTLA4	2.421 ± 6.216	3.026 ± 0.834	16.42 ± 15.00	68.02 ± 26.53*	54.42 ± 21.72*
GZMB	0.966 ± 0.291	2.495 ± 0.456	8.394 ± 11.47*	5.305 ± 2.977	9.108 ± 5.886*
IFNg	0.726 ± 0.542	2.005 ± 0.742	10.54 ± 15.36	4.594 ± 3.200	13.22 ± 12.45*
IL10	1.377 ± 0.981	2.526 ± 0.975	5.493 ± 4.593*	3.301 ± 1.454	2.677 ± 2.072
PTGS2	1.245 ± 0.844	3.818 ± 3.132	1.877 ± 2.350	4.594 ± 10.00	2.163 ± 1.499
TGFb1	1.251 ± 0.576	3.885 ± 3.301	1.669 ± 1.321	1.826 ± 0.698	2.835 ± 2.072
TNF	2.658 ± 5.417	3.333 ± 2.303	3.148 ± 3.013	3.721 ± 1.815	20.51 ± 26.49*

Data is expressed as the mean RQ ± SD. N: number of mice samples analyzed; “—”: not done. “*” Significant (𝑃<0.05) with respect to control.