PI3K Functions in Cancer Progression, Anticancer Immunity and Immune Evasion by Tumors

Table 1

Main effects of the PI3K and VEGFR inhibitors on immune cells.

PI3K inhibitors	p110 isoform	VEGFR2/3 inhibitors	Effect	Ref.
PIK-75	α		Reduced production of TNF-α and IL-6, reduced expression of human endothelial cell adhesion molecules (E-selectin, ICAM-1, and VCAM-1), and human monocyte-endothelial cell adhesion.	[79]
AS-605240	γ		Reduced numbers of infiltrated proinflammatory macrophages and T cells.	[80, 81]
AS041164	γ		Reduced RANTES-induced chemotaxis/recruitment.	[82]
CAL-101	δ		Apoptosis of CLL cells and decreased production of various inflammatory and antiapoptotic cytokines by activated T cells.	[72]
IC87114	δ		Reduced antigen-induced airway infiltration of inflammatory cells, secretion of T(H)2 cytokines in lungs, and inhibition of monocytic integrin activation during diapedesis.	[83]
		SU5416	Reduced IFNγ secretion by CD4+ CD45RO+ T cells.	[84]
		E7080	Reduced lymphocytes in tumor.	[85]
		TSU68	Decreased expression of CXCL1 (by cancer cells) and IL-12 and reduced neutrophil migration into tumor.	[86]