Th2 Regulation of Viral Myocarditis in Mice: Different Roles for TLR3 versus TRIF in Progression to Chronic Disease

Figure 3

TRIF-deficient mice develop significantly worse heart function at day 10 pi. Echocardiography was used to assess heart function in (a) TLR3-deficient (TLR3−/−) versus WT B6.129 mice, (b) TRIF-deficient (TRIF−/−) versus WT BL/6 mice, or (c) TLR3- versus TRIF-deficient mice. LVEDD, left ventricular end diastolic dimension; LVESD, left ventricular end systolic dimension; FS, fractional shortening; EF, ejection fraction. Data show the mean ± SEM of at least three separate experiments using 7 to 12 mice/group. *:𝑃<0.05; **:𝑃<0.01; ***:𝑃<0.001.

(a)

(b)

(c)