Th2 Regulation of Viral Myocarditis in Mice: Different Roles for TLR3 versus TRIF in Progression to Chronic Disease

Figure 8

Recombinant IL-33 treatment increases myocarditis and cardiac dysfunction in BL/6 mice. Male BL/6 mice were treated with recombinant IL-33 (rIL-33) or PBS every other day from day 1 to 9 pi and (a,c) myocarditis, (b) cardiac IL-33 levels by ELISA and (d) heart function assessed using pressure-volume relationships at day 10 pi. (c) Representative histology sections of inflammation in PBS-treated (left) and rIL-33-treated (right) BL/6 mice stained with H&E, magnification ×64. Data show the mean ± SEM of 10 mice/group. **:𝑃<0.01; ***:𝑃<0.001.

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