Th2 Regulation of Viral Myocarditis in Mice: Different Roles for TLR3 versus TRIF in Progression to Chronic Disease

Table 1

Similarity in cardiac function of C57BL/6 versus B6.129 mice prior to infection (day 0) and during acute (day 10) or chronic (day 35) CVB3 myocarditis based on pressure-volume analysis.

	Day 0		Day 10 pi		Day 35 pi
Parameter	BL/6	B6.129	BL/6	B6.129	BL/6	B6.129
HR	591 ± 3.9	596 ± 3.7	535 ± 6.0	567 ± 11.5*	569 ± 9.0	601 ± 5.7**
ESP	114 ± 2.1	111 ± 3.8	98 ± 2.1	108 ± 2.6**	109 ± 3.9	116 ± 3.4
EDP	6.3 ± 0.6	6.9 ± 2.5	4.1 ± 0.5	5.5 ± 0.5	4.8 ± 0.4	4.6 ± 0.7
dP/dT Max	11336 ± 463	10766 ± 250	10019 ± 538	10241 ± 395	11042 ± 852	10658 ± 555
dT/dT Min	−10628 ± 290	−10022 ± 309	−8484 ± 306	−9549 ± 454	−10017 ± 528	10852 ± 432
EF	71 ± 4.3	74 ± 2.2	58 ± 3.5	66 ± 5.7	69 ± 4.4	69 ± 2.4
ESV	5.7 ± 1.1	4.0 ± 0.4	10 ± 1.1	7.4 ± 1.8	6 ± 1.0	4 ± 0.2
EDV	18 ± 1.2	16 ± 1.0	24 ± 1.2	18 ± 2.5	18 ± 1.7	14 ± 0.7
CO	7499 ± 408	6940 ± 318	7276 ± 495	6083 ± 485	6885 ± 672	5960 ± 417
Ees	9.2 ± 0.8	8.3 ± 0.9	7.5 ± 0.5	8.4 ± 1.0	11.5 ± 1.2	15 ± 1.4
Ea/Ees	1.05 ± 0.1	1.3 ± 0.2	1.0 ± 0.0	1.1 ± 0.2	0.9 ± 0	0.8 ± 0.06
V0	−7.7 ± 1.3	−11.3 ± 1.6	−5.4 ± 1.2	−6.4 ± 2.1	−4.2 ± 1.9	−5.6 ± 1.0
Tau	5.2 ± 0.2	5.1 ± 0.3	5.6 ± 0.2	5.6 ± 0.2	5.6 ± 0.2	5.1 ± 0.2

CO (μL/min), cardiac output; dP/dT Max, peak rate of pressure rise (mmHg/s); dP/dT Min, peak rate of pressure decline (mmHg/s); Ea/Ees, arterial elastance normalized to Ees; EDP (mmHg), end diastolic pressure; EDV (μL), end diastolic volume; Ees (mmHg/μL), LV end systolic elastance (stiffness); EF (%), ejection fraction; ESP (mmHg), end systolic pressure; ESV (μL), end systolic volume; HR (bmp), heart rate; PFR/EDV (s⁻¹), peak flow rate normalized to EDV; PMX/EDV², maximum ventricular power normalized to EDV² (mW/μL²) × 100; PRSW (mmHg), preload recruitable stroke work; SV (μL), stroke volume; SW, stroke work; Tau, Weiss (ms), time constant of diastolic relaxation; V₀ (μL), X-intercept of the ESP-volume relationship. *∶𝑃<0.05, **∶𝑃<0.01, and ***∶𝑃<0.001 compare BL/6 to B6.129 by Student’s t-test at each timepoint. Data shown as mean ± SEM for 10 mice/group per timepoint.