Immune Responses to RHAMM in Patients with Acute Myeloid Leukemia after Chemotherapy and Allogeneic Stem Cell Transplantation
Figure 5
RHAMM-specific CTLs in a patient during relapse of AML. Release of both IFN-γ (upper panel) and granzyme B (lower panel) by RHAMM-specific CTLs was detected by ELISPOT in peripheral blood ((a), (b)) and bone marrow ((c), (d)) of a patient at the time of relapse. This population was lost following treatment with azacitidine and conditioning according to the FLAMSA protocol [6] followed by allo-SCT. Cells were not enough to perform flow cytometry analysis. Please note different y-axis scaling in this figure.
