Research Article
Immunological and Nonimmunological Effects of Indoleamine 2,3-Dioxygenase on Breast Tumor Growth and Spontaneous Metastasis Formation
Table 1
Spontaneous lung metastases formation by 4T1/Ido1+, 4T1/Ido1− or NT-5/Ido1+, NT-5/Ido1− tumors in immunocompetent and immunodeficient mice.
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1BALB/c and SCID-beige were inoculated s.c. with 2.5 × 104 4T1/Ido1+ or 4T1/Ido1− tumor cells. FVB/N and SCID-beige were inoculated s.c. with 5 × 106 NT-5/Ido1+ or NT-5/Ido1− tumor cells. When tumors reached about 2 cm in diameter, lungs were harvested and fixed in the Bounce solution. Metastases were counted under dissecting microscope. *Significantly () differ from all other groups. |