| (a) Villous explant cultures at 6% Oxygen |
| | Marker (pg/mL/g) | Normal karyotype | Abnormal karyotype | | Day of culture | Day | | 1 | 2 | 3 | 1 | 2 | 3 | | Mean | (95% CI) | Mean | (95% CI) | Mean | (95% CI) | Mean | (95% CI) | Mean | (95% CI) | Mean | (95% CI) |
| | TNFα Homo | 7.0 | (4.0, 12.4) | 20.6 | (5.3, 79.9) | 6.0 | (0.8, 44.9) | 25.4 | (14.1, 45.8) | 26.9 | (12.2, 59.2) | 17.3 | (6.7, 44.6) | | IL-10 Homo | 0.3 | (0.2, 0.4) | 0.8 | (0.4, 1.9) | 0.4 | (0.2, 0.9) | 1.0 | (0.6, 1.7) | 0.9 | (0.4, 2.3) | 1.3 | (0.6, 2.9) | | TNF-R2 Homo | 995.9 | (469.1, 2114.3) | 2334.6 | (740.5, 7360.2) | 841.6 | (274.1, 2584.4) | 3159.2 | (1804.8, 5530.2) | 4243.4 | (2901.4, 6206.2) | 4279.2 | (2045.4, 8952.8) | | TNF-R1 Homo | 314.0 | (174.4, 565.5) | 517.5 | (252.2, 1061.9) | 246.7 | (161.4, 377.2) | 330.3 | (176.9, 616.7) | 600.3 | (311.3, 1157.6) | 278.4 | (106.7, 726.2) | | TNFα/IL10 Homo | 24.7 | (14.2, 42.9) | 25.5 | (4.9, 131.3) | 14.7 | (4.1, 52.2) | 22.0 | (12.7, 37.9) | 20.0 | (10.0, 40.0) | 13.4 | (7.6, 23.8) | | TNFα CM | 238.6 | (87.3, 651.9) | 40.4 | (20.4, 80.0) | 53.6 | (3.3, 863.7) | 273.1 | (156.1, 477.9) | 213.2 | (125.5, 362.2) | 294.2 | (179.1, 483.4) | | IL-10 CM | 134.1 | (11.0, 1628.1) | 2.1 | (0.1, 41.6) | 3.6 | (0.1, 929.5) | 67.1 | (11.1, 404.4) | 83.5 | (6.2, 1116.6) | 37.0 | (2.5, 552.4) | | TNF-R2 CM | 1371.3 | (504.9, 3724.8) | 2276.1 | (827.3, 6262.5) | 2712.2 | (1972.4, 3729.5) | 1109.1 | (364.4, 3375.9) | 5120.8 | (2835.5, 9248.1) | 6735.4 | (3554.1, 12764.3) | | TNF-R1 CM | 471.1 | (202.5, 1095.9) | 430.0 | (216.5, 854.0) | 472.2 | (389.9, 571.8) | 645.0 | (478.4, 869.6) | 1316.6 | (882.2, 1964.9) | 1186.4 | (612.7, 2297.2) | | TNFα/IL10 CM | 1.8 | (0.3, 9.1) | 19.2 | (1.8, 200.9) | 15.0 | (0.7, 335.4) | 3.6 | (0.9, 14.2) | 2.9 | (0.3, 24.6) | 8.0 | (0.7, 86.6) |
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| (b) Villous explant cultures at 20% oxygen |
| | Marker (pg/mL/g) | Normal karyotype | Abnormal karyotype | | Day of culture | Day of culture | | 1 | 2 | 3 | 1 | 2 | 3 | | Mean | (95% CI) | Mean | (95% CI) | Mean | (95% CI) | Mean | (95% CI) | Mean | (95% CI) | Mean | (95% CI) |
| | TNFα Homo | 18.9 | (7.2, 50.0) | 22.0 | (5.0, 95.5) | 2.5 | (0.7, 8.7) | 20.3 | (10.1, 40.9) | 32.6 | (18.2, 58.2) | 27.9 | (13.4, 57.8) | | IL-10 Homo | 1.0 | (0.4, 2.7) | 0.3 | (0.2, 0.7) | 0.2 | (0.1, 0.6) | 1.9 | (0.9, 3.8) | 2.2 | (1.0, 5.0) | 1.1 | (0.5, 2.4) | | TNF-R2 Homo | 3121.9 | (1859.5, 5241.1) | 1939.0 | (562.8, 6680.3) | 1107.7 | (202.1, 6070.6) | 3713.7 | (2408.8, 5725.5) | 4967.9 | (2460.7, 10029.7) | 3789.8 | (2045.8, 7020.4) | | TNF-R1 Homo | 463.1 | (218.9, 980.0) | 430.6 | (179.1, 1035.4) | 370.6 | (222.5, 617.3) | 551.3 | (318.5, 954.2) | 645.2 | (347.8, 1197.2) | 738.0 | (393.5, 1384.3) | | TNFα CM | 334.9 | (164.4, 681.9) | 44.1 | (12.5, 174.8) | 45.8 | (5.1, 411.8) | 241.8 | (118.3, 494.4) | 332.1 | (165.8, 665.2) | 218.5 | (54.6, 874.2) | | IL-10 CM | 304.3 | (43.6, 2124.4) | 0.4 | (0.1, 2.2) | 6.5 | (0.1, 846.3) | 686.6 | (208.8, 2257.4) | 180.6 | (13.7, 2376.3) | 55.0 | (3.7, 819.0) | | TNF-R2 CM | 2359.1 | (1379.8, 4033.3) | 2312.6 | (840.1, 6365.5) | 2850.6 | (2717.6, 2990.2) | 2681.1 | (1837.1, 3912.9) | 3683.9 | (2561.3, 5298.4) | 4874.7 | (3758.0, 6323.1) | | TNF-R1 CM | 531.1 | (338.7, 832.9) | 554.5 | (499.2, 615.9) | 638.7 | (517.2, 788.9) | 661.6 | (513.1, 853.1) | 1177.5 | (780.4, 1776.5) | 1208.5 | (883.4, 1653.2) | | TNFα/IL10 Homo | 18.8 | (10.4, 34.1) | 66.5 | (24.3, 181.9) | 11.0 | (5.5, 22.3) | 13.9 | (9.4, 20.5) | 14.8 | (8.1, 27.2) | 15.3 | (7.4, 31.9) | | TNFα/IL10 CM | 1.9 | (0.4, 8.6) | 105.2 | (13.1, 844.8) | 4.0 | (0.1, 365.6) | 0.8 | (0.3, 2.5) | 1.8 | (0.2, 13.6) | 4.0 | (0.8, 20.2) |
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