The Impact of Osteopontin Gene Variations on Multiple Sclerosis Development and Progression

Table 1

Frequency distribution of OPN +1239A > C genotypes in MS patients and healthy controls.

Genotype SNP + 1239	*MS (𝑛=728)	^†Controls (𝑛=1218)
AA	335 (46)	634 (52)
AC	314 (43)	486 (40)
CC	79 (11)	98 (8)
AA	335 (46)	634 (52)
Non-AA	393 (54)	584 (48)
	^‡OR = 1.27 𝑃=0.011 (95% CI: 1.05–1.54)

* Multiple sclerosis patients.
^†number of subjects and proportions are shown in the brackets. Genotypic distribution did not deviate significantly from the Hardy-Weinberg equilibrium in any group (data not shown).
^‡Odds ratio (OR), 95% confidence limits (95% CI), 𝜒² test calculated on allelic frequencies, and 𝑃 values are 2-tailed.