Research Article
The Impact of Osteopontin Gene Variations on Multiple Sclerosis Development and Progression
Table 3
Frequency distribution of different outcomes in MS patients carrying different OPN genotypes.
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aPatients displaying RR form (slow progressive) or EDSS ≤ 3 (benign MS) after 10 years from onset. bNumber of patients displaying that disease status; proportions are shown in brackets. Patients displaying either RR course and less than 10 years of followup (29/728) or PP course (71/728) were excluded from the analysis of progression. Patients displaying EDSS ≤ 3.0 and less than 10 years of followup (88/728) were excluded from the analysis of disability. cPatients switching to SP form (fast progressive) or reaching EDSS > 3 (non-benign MS) within 10 years from onset. dStatistical analysis was performed by comparing the different outcomes with the test. Total number in the analysis of progression: 628 patients: 285 AA; 343 non-AA; 76 GG; 552 non-GG; 60 AAGG; 568 non-AAGG. Total number in the analysis of course 640 patients: 293 AA, 347 non-AA; 78 GG, 562 non-GG; 67 AAGG, 573 non-AAGG. |