Research Article

Dietary Supplementation with Omega-3-PUFA-Rich Fish Oil Reduces Signs of Food Allergy in Ovalbumin-Sensitized Mice

Figure 5

Dietary supplementation with n-3 PUFA decreases leukocyte rolling in small intestine of BALB/c-sensitized mice. BALB/c mice received 5% n-3 PUFA (control group) or 25% n-3 PUFA (n-3 PUFA group) as source of lipids in their diet 21 days before the sensitization. BALB/c mice were sensitized (allergic, OVA+) or not (nonallergic, OVA) with OVA. Seven days after the booster, all mice received OVA diet. After seven days of ingestion of the ovalbumin- (OVA-) containing diet, the leukocyte rolling (a) and adhesion (b) to the microvasculature of intestine were assayed by intravital microscopy. Data are reported as means ± SEM for 3 mice in each group. * compared to control group (ANOVA-Tukey).
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(a)
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(b)