Perinatal Gene-Gene and Gene-Environment Interactions on IgE Production and Asthma Development
Figure 1
Mechanisms of pre- and postnatal environmental factors on the development of asthma. A number of prenatal factors such as maternal diet with methyl donors, maternal atopy, TSE, and oxidative stress could alter the epigenetic programming of Th2 and redox genes, resulting in the allergic sensitization and diseases (a). Additional postnatal environmental conditions such as pollution, secondhand TSE, pets exposure, infant diets and microbiota may modulate or drive the expression of Treg and/or Th1/Th2 genes resulting in skewed or balanced Th2 responses that contribute to persistence or remission of allergic diseases (b).
