Perinatal Gene-Gene and Gene-Environment Interactions on IgE Production and Asthma Development

Table 2

Interactions of genes with maternal atopy, endotoxin and other environmental factors on IgE production and asthma phenotype.

		Environment factors-gene interaction
Prenatal	Cord blood IgE levels	Maternal atopy-FGF1 [10]
		Maternal atopy-IL13-CCL22 [10]
		Maternal atopy-gender-CTLA4 [46]
		Endotoxin-CD14 [47]
Childhood	IgE levels	Animal contact-CD14 [48]
		Helicobacter pylori-CD14 [49]
		Endotoxin-CD14 [50]
		Day care attendance-CD14 [51]
		Day care attendance-IL4R [51]
	Asthma	Country living-CD14 [52]
		Fungi-CHIT1 [53]
		Maternal bronchial hyperresponsiveness-HLA-G [54]
		Children of farmer-TLR2 [55]