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Clinical and Developmental Immunology
Volume 2012 (2012), Article ID 278059, 9 pages
Lack of Intestinal Epithelial Atg7 Affects Paneth Cell Granule Formation but Does Not Compromise Immune Homeostasis in the Gut
1Medical Clinic 1, Friedrich-Alexander-University Erlangen-Nuremberg, 91054 Erlangen, Germany
2Department of Nephropathology, Friedrich-Alexander-University Erlangen-Nuremberg, 91054 Erlangen, Germany
Received 14 June 2011; Revised 26 September 2011; Accepted 3 October 2011
Academic Editor: Ana Maria Caetano Faria
Copyright © 2012 Nadine Wittkopf et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- M. A. Stone, J. F. Mayberry, and R. Baker, “Prevalence and management of inflammatory bowel disease: a cross-sectional study from central England,” European Journal of Gastroenterology & Hepatology, vol. 15, no. 12, pp. 1275–1280, 2003.
- G. Pickert, C. Neufert, M. Leppkes et al., “STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing,” The Journal of Experimental Medicine, vol. 206, no. 7, pp. 1465–1472, 2009.
- M. L. Hermiston and J. I. Gordon, “Inflamatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin,” Science, vol. 270, no. 5239, pp. 1203–1207, 1995.
- J. D. Rioux, R. J. Xavier, K. D. Taylor et al., “Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis,” Nature Genetics, vol. 39, no. 5, pp. 596–604, 2007.
- J. C. Barrett, S. Hansoul, D. L. Nicolae et al., “Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease,” Nature Genetics, vol. 40, no. 8, pp. 955–962, 2008.
- J. Alegre-Abarrategui and R. Wade-Martins, “Parkinson disease, LRRK2 and the endocytic-autophagic pathway,” Autophagy, vol. 5, no. 8, pp. 1208–1210, 2009.
- A. Eisenberg-Lerner, S. Bialik, H. U. Simon, and A. Kimchi, “Life and death partners: apoptosis, autophagy and the cross-talk between them,” Cell Death and Differentiation, vol. 16, no. 7, pp. 966–975, 2009.
- F. Cecconi and B. Levine, “The role of autophagy in mammalian development: cell makeover rather than cell death,” Developmental Cell, vol. 15, no. 3, pp. 344–357, 2008.
- G. Mariño, A. F. Fernández, and C. López-Otín, “Autophagy and aging: lessons from progeria models,” Advances in Experimental Medicine and Biology, vol. 694, pp. 61–68, 2010.
- X. Qu, Z. Zou, Q. Sun et al., “Autophagy gene-dependent clearance of apoptotic cells during embryonic development,” Cell, vol. 128, no. 5, pp. 931–946, 2007.
- V. Deretic, “Multiple regulatory and effector roles of autophagy in immunity,” Current Opinion in Immunology, vol. 21, no. 1, pp. 53–62, 2009.
- M. Komatsu, S. Waguri, T. Ueno et al., “Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice,” Journal of Cell Biology, vol. 169, no. 3, pp. 425–434, 2005.
- A. Kuma, M. Hatano, M. Matsui et al., “The role of autophagy during the early neonatal starvation period,” Nature, vol. 432, no. 7020, pp. 1032–1036, 2004.
- T. Saitoh, N. Fujita, M. H. Jang et al., “Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production,” Nature, vol. 456, no. 7219, pp. 264–268, 2008.
- M. Komatsu, S. Waguri, T. Chiba et al., “Loss of autophagy in the central nervous system causes neurodegeneration in mice,” Nature, vol. 441, no. 7095, pp. 880–884, 2006.
- B. B. Madison, L. Dunbar, X. T. Qiao, K. Braunstein, E. Braunstein, and D. L. Gumucio, “cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine,” The Journal of Biological Chemistry, vol. 277, no. 36, pp. 33275–33283, 2002.
- M. F. Neurath, N. Wittkopf, A. Wlodarski et al., “Assessment of tumor development and wound healing using endoscopic techniques in mice,” Gastroenterology, vol. 139, no. 6, pp. 1837–e1, 2010.
- C. Becker, M. C. Fantini, and M. F. Neurath, “High resolution colonoscopy in live mice,” Nature Protocols, vol. 1, no. 6, pp. 2900–2904, 2007.
- C. Becker, S. Wirtz, M. Blessing et al., “Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells,” Journal of Clinical Investigation, vol. 112, no. 5, pp. 693–706, 2003.
- Y. Uchiyama, M. Shibata, M. Koike, K. Yoshimura, and M. Sasaki, “Autophagy-physiology and pathophysiology,” Histochemistry and Cell Biology, vol. 129, no. 4, pp. 407–420, 2008.
- I. Tanida and S. Waguri, “Measurement of autophagy in cells and tissues,” Methods in Molecular Biology, vol. 648, pp. 193–214, 2010.
- K. Cadwell, J. Y. Liu, S. L. Brown et al., “A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells,” Nature, vol. 456, no. 7219, pp. 259–263, 2008.
- A. J. Ouellette, “Paneth cells and innate mucosal immunity,” Current Opinion in Gastroenterology, vol. 26, no. 6, pp. 547–553, 2010.
- K. Cadwell, K. K. Patel, M. Komatsu, H. W. Virgin, and T. S. Stappenbeck, “A common role for Atg16L1, Atg5 and Atg7 in small intestinal Paneth cells and Crohn disease,” Autophagy, vol. 5, no. 2, pp. 250–252, 2009.
- J. Wehkamp, J. Harder, M. Weichenthal et al., “NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal α-defensin expression,” Gut, vol. 53, no. 11, pp. 1658–1664, 2004.
- L. A. Simms, J. D. Doecke, M. D. Walsh, N. Huang, E. V. Fowler, and G. L. Radford-Smith, “Reduced α-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease,” Gut, vol. 57, no. 7, pp. 903–910, 2008.
- T. Hara, K. Nakamura, M. Matsui et al., “Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice,” Nature, vol. 441, no. 7095, pp. 885–889, 2006.
- L. G. van der Flier and H. Clevers, “Stem cells, self-renewal, and differentiation in the intestinal epithelium,” Annual Review of Physiology, vol. 71, pp. 241–260, 2009.
- A. Kaser, A. H. Lee, A. Franke et al., “XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease,” Cell, vol. 134, no. 5, pp. 743–756, 2008.
- U. S. Gaipl, A. Sheriff, S. Franz et al., “Inefficient clearance of dying cells and autoreactivity,” Current Topics in Microbiology and Immunology, vol. 305, pp. 161–176, 2006.
- K. Cadwell, K. K. Patel, N. S. Maloney et al., “Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine,” Cell, vol. 141, no. 7, pp. 1135–1145, 2010.