Herpes Simplex Virus-2 Glycoprotein Interaction with HVEM Influences Virus-Specific Recall Cellular Responses at the Mucosa
Figure 1
HSV-2 titers in the vaginal tract after infection with the attenuated viruses HSV-2(333)/gD-βgal or HSV-2(333)/Δ7-15-βgal are only minimally affected by engagement of HVEM. Viral titers were measured in vaginal secretions on the days indicated after virus inoculation. Five mice per group were inoculated intravaginally with PFU of HSV-2(333)/gD-βgal (open circles) or HSV-2(333)/Δ7-15-βgal (filled triangles). Symbols denote mean titers (±standard deviation) for each group. There was a statistically significant difference () in mean titer on day 1, with approximately 0.5 log lower titer of HSV-2(333)/Δ7-15-βgal at this time point. Measured titers were statistically equivalent at subsequent time points.
