Non-MHC Risk Alleles in Rheumatoid Arthritis and in the Syntenic Chromosome Regions of Corresponding Animal Models

Table 1

Arthritis-associated QTLs of mice corresponding to human SNP-based GWAS.

mChr	Markers	Region (Mbp)	Locus name (mouse)	Peak marker name	Peak marker position	Mouse gene; And its position (Mbp)		References; (mouse)	Corresponding human Chr position (Mbp)		Human locus name
1	D1Mit188–; D1Mit122	3.9–40.5	mCia14	D1Mit244	37.6	Aff3	(38.2)	[9, 40, 92, 93]	2q11	(100.2)	AFF3
1	D1Mit426–; D1Mit209	90.4–193.3	mCia9; Pgia1	D1Mit166	178.3	Fcgr2b	(170.9)	[57, 92, 93]	1q23	(172.9)	FCGR2A
			Pia(Chr1)	D1Mit36	171.1
2	D2Mit79–; D2Mit237	21.9–40.8	mCia2; mCia4	D2Mit238	33.9	Traf1 /Hc	(34.8)	[2, 40–44]	9q33	(123.6)	TRAF1/ C5
			Pgia2; HS	D2Mit81	33.4
3	D3Mit75–; D3Mit284	100.5–103.6	mCia21; mCia22	D2Mit75; D2Mit284	100.5; 103.6	Cd2; Ptpn22	(100.5); (103.6)	[45, 46]	1p23; 1p13	(114.3); (117.3)	CD22; PTPN22
3	D3Mit141.1–D3Mit323	93.0–152.4	Pgia26; (+3 subloci)	D3Mit158	109.1	Cd2; Ptpn22	(100.5); (103.6)	[47, 47, 48, 57, 92, 93]	1p13; 1p23	(114.3); (117.3)	CD22; PTPN22
			Pia-Chr3	D3Mit100	96.8
5	D5Mit388–; D5Mit256	33.8–63.3	Pgia16; mCia13	D5Mit233	53.0	Rbjp	(53.9)	[9, 44, 49]	4p15	(25.8)	RBJP
6	D6Mit86–; D6Mit318	4.4–65.1	Pgia19	D6Mit267	29.2	Irf5	(29.4)	[40, 50, 93]	7q32	(128.2)	IRF5
10	D10Mit206–; D10Mit130	13.8–65.9	Pgia6; Pgia6b	D10Mit124	20.9	Tnfaip3; Prdm1	(18.7); (44.1)	[9, 40, 43, 92, 93]	6q23; 6q21	(138.2); (106.5)	TNFAIP3; PRDM1
10	D10Mit12–; D10Mit269	98.9–128.4	mCia8; (“locus 5”); AIL(Chr10)	D10Mit102; D10Mit261	120.3; 85.0	Kif5a; Pip4k2c	(126.7); (126.6)	[40, 50, 58, 58, 94]	12q13; 12q13	(57.9); (57.9)	KIF5A; PIP4K2C
13	D13Mit258–; D13Mit78	95.6–119.6	Pgia15; mCia19	D13Mit51; D13Mit53	105.3; 113.1	Ankrd55; IL6st	(113.0); (113.2)	[9, 44, 51, 92, 93]	5q11; 5q11	(55.4); (55.2)	ANKRD55; IL6ST
15	D15Mit121–; D15Mit242	57.9–90.2	Pgia9	D15Mit28	74.4	IL2b; Bik	(78.3); (83.4)	[9, 40, 44, 62, 92, 93]	22q12; 8p3	(37.5); (11.3)	IL2RB; BIK
15	D15Mit279–; D15Mit192	74.0–92.7	mCia35–mCia37	D15Mit159	87.3	IL2b; Bik	(78.3); (83.4)	[53]	22q12; 8p3	(37.5); (11.3)	IL2RB; BIK
18	D18Mit51–; D18Mit80	61.3–77.0	Pgia11	D18Mit81	66.7	Ptpn2	(67.8)	[9, 40, 43, 93]	18p11.3–p11.2	(12.8)	PTPN2

Human RA loci validated in Caucasian, African American, and Asian ancestry and compared via meta-analysis [17, 18, 54, 55, 59–61, 63].
Human RA loci validated in Caucasian, African American, and Asian ancestry and compared via meta-analysis [17, 18, 54, 55, 59–61, 63].