Table 1: Arthritis-associated QTLs of mice corresponding to human SNP-based GWAS.

mChrMarkersRegion (Mbp)Locus name (mouse)Peak marker namePeak marker position Mouse gene
And its position (Mbp)
References
(mouse)
Corresponding human Chr position (Mbp) Human locus name

1D1Mit188–
D1Mit122
3.9–40.5mCia14 D1Mit24437.6Aff3(38.2)[9, 40, 92, 93]2q11(100.2)AFF3
1D1Mit426–
D1Mit209
90.4–193.3mCia9   
Pgia1
D1Mit166178.3Fcgr2b(170.9)[57, 92, 93]1q23(172.9)FCGR2A
Pia(Chr1) D1Mit36171.1
2D2Mit79–
D2Mit237
21.9–40.8mCia2  
mCia4
D2Mit23833.9Traf1 /Hc(34.8)[2, 4044]9q33(123.6)TRAF1/ C5
Pgia2   
HS
D2Mit8133.4
3D3Mit75–
D3Mit284
100.5–103.6mCia21
mCia22
D2Mit75
D2Mit284
100.5
103.6
Cd2  
Ptpn22
  (100.5)  
(103.6)
[45, 46]1p23  
1p13
  (114.3)   
(117.3)
CD22
PTPN22
3 D3Mit141.1–D3Mit32393.0–152.4Pgia26
(+3 subloci)
D3Mit158109.1Cd2  
Ptpn22
  (100.5)   
(103.6)
[47, 47, 48, 57, 92, 93]1p13  
1p23
  (114.3)   
(117.3)
CD22
PTPN22
Pia-Chr3D3Mit10096.8
5D5Mit388–
D5Mit256
33.8–63.3Pgia16
mCia13
D5Mit23353.0Rbjp(53.9)[9, 44, 49]4p15(25.8)RBJP
6D6Mit86–
D6Mit318
4.4–65.1Pgia19 D6Mit26729.2Irf5(29.4)[40, 50, 93]7q32(128.2)IRF5
10D10Mit206–
D10Mit130
13.8–65.9Pgia6   
Pgia6b
D10Mit12420.9Tnfaip3  
Prdm1
  (18.7)  
(44.1)
[9, 40, 43, 92, 93]6q23  
6q21
  (138.2)   
(106.5)
TNFAIP3  
PRDM1
10D10Mit12–
D10Mit269
98.9–128.4mCia8  
(“locus 5”)
AIL(Chr10)
D10Mit102
D10Mit261
120.3
85.0
Kif5a  
Pip4k2c
  (126.7)  
(126.6)
[40, 50, 58, 58, 94]12q13  
12q13
  (57.9)   
(57.9)
KIF5A  
PIP4K2C
13D13Mit258–
D13Mit78
95.6–119.6Pgia15
mCia19
D13Mit51
D13Mit53
105.3
113.1
Ankrd55  
IL6st
  (113.0)  
(113.2)
[9, 44, 51, 92, 93]5q11  
5q11
  (55.4)   
(55.2)
ANKRD55  
IL6ST
15D15Mit121–
D15Mit242
57.9–90.2Pgia9 D15Mit2874.4IL2b  
Bik
  (78.3)  
(83.4)
[9, 40, 44, 62, 92, 93]22q12  
8p3
  (37.5)   
(11.3)
IL2RB
BIK
15D15Mit279–
D15Mit192
74.0–92.7mCia35–mCia37 D15Mit15987.3IL2b  
Bik
  (78.3)  
(83.4)
[53]22q12  
8p3
  (37.5)   
(11.3)
IL2RB
BIK
18D18Mit51–
D18Mit80
61.3–77.0Pgia11 D18Mit8166.7Ptpn2  (67.8)[9, 40, 43, 93]18p11.3–p11.2(12.8)PTPN2

Human RA loci validated in Caucasian, African American, and Asian ancestry and compared via meta-analysis [17, 18, 54, 55, 5961, 63].
Human RA loci validated in Caucasian, African American, and Asian ancestry and compared via meta-analysis [17, 18, 54, 55, 5961, 63].