Indirect Effects of Oral Tolerance Inhibit Pulmonary Granulomas to Schistosoma mansoni Eggs
Figure 6
Cytokines production of lungs. Fourteen days after i.v. injection of S. mansoni eggs in nonimmunized mice (granuloma group, open bars), OVA immune controls (hatched bars), and OVA-orally tolerant mice (black bars), lungs were removed and homogenized in extract buffer. Normal mice (doted bars) were not immunized with OVA and neither injected with eggs. Extract supernatant was collected for cytokine assay. IFN-γ, TNF-α, IL-2, IL-4, and IL-5 were measured using a Cytometric Bead Array (CBA) kit. The results are shown as mean concentrations ± SEM. nd: not detected.
