Indirect Effects of Oral Tolerance Inhibit Pulmonary Granulomas to Schistosoma mansoni Eggs
Figure 8
IFN-γ and IL-10 production of spleen cells stimulated with SEA or OVA. Eighteen days after i.v. injection of S. mansoni eggs in nonimmunized mice (granuloma group, open bars), OVA immune controls (hatched bars), and OVA-orally tolerant mice (black bars) spleen cells were cultured with medium, ConA, SEA or OVA for 3 days. Normal mice (doted bars) were not immunized with OVA neither injected with eggs. The culture supernatant fluids were harvested and IFN-γ and IL-10 measured by sandwich ELISA. The results are shown as mean concentrations ± SEM. nd: not detected.
