Adaptive and Innate Immune Responsiveness to Borrelia burgdorferi sensu lato in Exposed Asymptomatic Children and Children with Previous Clinical Lyme Borreliosis

Figure 1

The number of Borrelia-specific IFN-γ-secreting cells (open circle), IL-4-secreting cells (open square) and IL-17-secreting cells (open triangle), per 100 000 PBMCs as measured by ELISPOT in different groups. The filled circles, squares, and triangles represent children in the previous clinical LB group with Borrelia seropositivity. The Borrelia-specific secretions are net values obtained after subtracting the number of spontaneous cytokine-secreting cells from the number of outer surface protein fraction (OF-) antigen-specific cytokine-secreting cells. The median values are noted as lines in the figure. No statistically significant differences were found between groups.