The Genetic Polymorphisms of HLA Are Strongly Correlated with the Disease Severity after Hantaan Virus Infection in the Chinese Han Population

Table 1

Clinical characteristics of the study subjects.

		HFRS patients		Controls
	Total	Mild/Moderate	Severe/Critical
	𝑛=76	𝑛=35	𝑛=41	𝑛=370
Mean age (year)^a	42 (40–44)	41 (38–44)	43 (40–46)	40 (39–41)
Male (%)^a	63.2	57.1	68.3	59.5
Number of stages in HFRS^b	3–5	3-4	4-5	—
Mean course (days)^c	20 (18–21)	15 (14–16)**	24 (22–26)**	—
Mean S-BUNmax (mmol/L)	20.4 (17.9–22.9)	14.4 (11.6–17.3)**	25.6 (22.3–28.8)**	—
Mean S-Creamax (μmol/L)	444.0 (391.2–496.8)	367.2 (288.5–445.9)*	509.6 (442.0–577.2)*	—
Mean B-Leukmax (*10^9/L)	24.3 (20.3–28.3)	19.0 (15.5–22.6)*	28.8 (22.3–35.3)*	—
Mean B-Thrommin (*10^9/L)	28.4 (23.1–33.6)	41.8 (33.3–50.3)**	16.9 (12.8–21.0)**	—
Mean S-ALBmin (g/L)	27.9 (26.6–29.2)	31.6 (30.1–33.2)**	24.7 (23.2–26.2)**	—

The continuous variables were presented as mean (95% confidence interval). The Mann-Whitney 𝑈 test was used to compare the groups; the Chi-square test was used for the percentage of men. HFRS: hemorrhagic fever with renal syndrome. 𝑛: number of patients; S-BUN_max: highest blood urea nitrogen; S-Crea_max: highest serum creatinine concentration; B-Leuk_max: highest blood leukocyte count; B-Throm_min: lowest blood thrombocyte count; S-ALB_min: lowest serum albumin concentration (all measured during hospital care).
^aThere were no differences pertaining to age and male percent between total HFRS patients and controls or between the milder group and the more severe group.
^bThe stages of HFRS include febrile, hypotensive, oliguric, diuretic, and convalescence.
^cThe days from fever onset to convalescence discharge from the hospital.
^∗∗𝑃<0.01 between the milder group and the more severe group.
^∗𝑃<0.05 between the milder group and the more severe group.