The Genetic Polymorphisms of HLA Are Strongly Correlated with the Disease Severity after Hantaan Virus Infection in the Chinese Han Population

Table 2

The polymorphism and susceptibility of class I and II loci in the major histocompatibility complex to hemorrhagic fever with renal syndrome.

Class, locus	Alleles	Number of alleles studied	df	Residual χ ^2	P
Class I
HLA-A	*02,*11,*31,*30,*33,*32,*01,*24,*03	9	9	6.17	0.722
HLA-B	*13,*40,*15,*58,*51,*07,*46,*44,*35,*54,*48,*52	12	12	10.74	0.551
Class II
HLA-DRB1	*07,*12,*04,*09,*11,*15,*14,*08,*03,*13	10	10	18.39	0.049

The alleles were selected for frequency >5%. Logistic regression was used for analysis. Locus in bold indicates that its polymorphism is linked to susceptibility to hemorrhagic fever with renal syndrome. Number in bold indicates a significant P value.