The Genetic Polymorphisms of HLA Are Strongly Correlated with the Disease Severity after Hantaan Virus Infection in the Chinese Han Population
Table 6
Comparison of the clinical laboratory findings in HLA allele or haplotype-positive and -negative hospitalized patients with hemorrhagic fever with renal syndrome.
Characteristics
HLA-B*46-DRB1*09 positive
HLA-B*46-DRB1*09 negative
P
HLA-B*51-DRB1*09 positive
HLA-B*51-DRB1*09 negative
P
HLA-B*46 positive
HLA-B*46 negative
P
Mean age (year)
44 (37–51)
42 (39–44)
0.428
46 (21–72)
42 (40–44)
0.334
43 (38–47)
42 (39–44)
0.360
Mean course (days)a
22 (17–27)
19 (18–21)
0.183
20 (12–29)
20 (18–21)
0.700
22 (18–25)
19 (17–21)
0.090
Mean s-BUNmax (mmol/L)
19.54 (11.06–28.02)
20.57 (17.94–23.20)
0.637
19.23 (4.41–42.88)
20.49 (17.97–23.01)
0.701
20.50 (14.32–26.69)
20.39 (17.65–23.14)
0.769
Mean s-Creamax (μmol/L)
596.01 (495.32–696.70)
418.30 (360.51–476.09)
0.011
690.02 (383.47–1004.60)
430.13 (377.04–483.22)
0.041
553.02 (469.03–637.00)
410.19 (347.53–472.86)
0.011
Mean Leukmax (*109/L)
16.69 (13.13–20.25)
25.59 (21.05–30.13)
0.275
18.06 (11.10–25.01)
24.65 (20.48–28.82)
0.798
24.55 (14.25–34.86)
24.23 (19.93–28.52)
0.797
Mean PLTmin (*109/L)a
48.36 (24.95–71.77)
34.97 (20.37–29.57)
0.073
43.00 (13.03–99.03)
27.54 (22.35–32.74)
0.334
39.33 (23.97–54.70)
24.95 (19.99–29.91)
0.087
Mean s-ALBmin (g/L)
30.36 (26.75–33.97)
27.46 (26.03–28.90)
0.125
30.03 (24.38–35.67)
27.77 (26.38–29.15)
0.451
28.98 (26.33–31.64)
27.54 (25.99–29.10)
0.766
The continuous variables were presented as mean (95% confidence interval). P value derived from the Mann-Whitney test or the Student’s -test. S-BUNmax: highest blood urea nitrogen; S-Creamax: highest serum creatinine concentration; B-Leukmax: highest blood leukocyte count; B-Thrommin: lowest blood thrombocyte count; S-ALBmin: lowest serum albumin concentration (all measured during hospital care). Numbers in bold indicate an almost significant P value.
aThe days from fever onset to convalescence discharge from the hospital.
