Reintroduction of Gluten Following Flour Transamidation in Adult Celiac Patients: A Randomized, Controlled Clinical Study

Table 1

Demographic data, clinical symptoms (GSRS) at diagnosis, and baseline laboratory investigations in 47 GFD CD patients.

	Group		𝑃 value^1
	Control	Experimental
n. pts	12	35
Age (years)^*	40 (23–50)	37 (18–53)	0.13
GFD (years)^*	3 (2–14)	8 (2–28)	0.07
Gender
Female	9	24
Male	3	11	1.00
GSRS
Abdominal pain	10	20	0.16
Constipation syndrome	0	3	0.56
Diarrhea syndrome	4	18	0.33
Indigestion syndrome	1	1	0.44
Reflux syndrome	2	4	0.63
Total^2	10	33	0.26
Nil	2	2
C/M ratio > 0.037
Baseline	2	1	0.15
Anti-tTG IgA titre (UA/mL)^*
Baseline	6 (2.3–10.3)	5 (1.0–35.0)	0.35

^* Median (range).
¹GSRS, intestinal permeability data and gender distribution were compared via Fisher’s exact test; the Mann Whitney test was used to analyze age, GFD and the anti-tTG IgA titre.
²Total number of patients manifesting at least one symptom.