Reintroduction of Gluten Following Flour Transamidation in Adult Celiac Patients: A Randomized, Controlled Clinical Study

Table 2

K-CH₃-gluten challenge: clinical and intestinal permeability assessment.

Time of challenge (days)	15			30		60	90
	Group^*		𝑃 value^1	Group		Group	Group
	ctr	exp		ctr	exp	exp	exp
n. pts	12	35		0	20	17	17
(A) C/M ratio > 0.037
Baseline	2	1	0.15
End	6	7	0.06	—	2	0	2
(B) GSRS
Abdominal pain	7	13	0.31	—	2	0	0
Constipation syndrome	5	0	0.0005	—	0	0	1
Diarrhea syndrome	2	2	0.26	—	1	0	0
Indigestion syndrome	2	0	0.06	—	0	0	0
Reflux syndrome	0	0	1.00	—	0	0	0
Total^2	9	13		—	0	0	0
Nil	3	22	0.04	—	18	17	16
Dropouts
Withdrawn for (A) or (B)	10	14		—	2	0	—
Withdrawn for other reasons	2	1		—	1	0

^∗ctr: control; exp: experimental.
¹Fisher’s exact test.
²Total number of patients manifesting at least one symptom.