Notch Signaling Mediates TNF-α-Induced IL-6 Production in Cultured Fibroblast-Like Synoviocytes from Rheumatoid Arthritis
Figure 3
Effect of TNF-α stimulation on IL-6 and Hes-1 production in OA FLSs. (a) OA and RA FLSs were incubated with TNF-α (10 ng/mL) for 24 h, and then the supernatants were collected and analyzed for the IL-6 production by ELISA; (b) OA and RA FLSs were incubated with TNF-α (10 ng/mL) for 24 h, and then the cells were collected and analyzed for the Hes-1 mRNA expression by PCR. Each column is the mean ± SD. *.
