About this Journal Submit a Manuscript Table of Contents
Clinical and Developmental Immunology
Volume 2012 (2012), Article ID 370107, 8 pages
http://dx.doi.org/10.1155/2012/370107
Research Article

BPI-ANCA and Long-Term Prognosis among 46 Adult CF Patients: A Prospective 10-Year Follow-Up Study

1Department of Respiratory Medicine and Allergology, Lund University and Skane University Hospital, 221 85 Lund, Sweden
2Department of Nephrology and Department of Clinical Sciences, Lund University, 221 85 Lund, Sweden
3Department of Medicine and Health, Linkoping University, 590 50 linkoping, Sweden
4Department of Nephrology UHL, County Council of Ostergotland, 581 85 Linkoping, Sweden

Received 27 September 2012; Accepted 22 October 2012

Academic Editor: Dimitrios P. Bogdanos

Copyright © 2012 Ulrika Lindberg et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. Schaedel, I. De Monestrol, L. Hjelte et al., “Predictors of deterioration of lung function in cystic fibrosis,” Pediatric Pulmonology, vol. 33, no. 6, pp. 483–491, 2002. View at Publisher · View at Google Scholar · View at Scopus
  2. E. F. McKone, C. H. Goss, and M. L. Aitken, “CFTR genotype as a predictor of prognosis in cystic fibrosis,” Chest, vol. 130, no. 5, pp. 1441–1447, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. E. Kerem, M. Corey, B. S. Kerem et al., “The relation between genotype and phenotype in cystic fibrosis—analysis of the most common mutation (ΔF508),” The New England Journal of Medicine, vol. 323, no. 22, pp. 1517–1522, 1990. View at Scopus
  4. E. F. McKone, S. S. Emerson, K. L. Edwards, and M. L. Aitken, “Effect of genotype on phenotype and mortality in cystic fibrosis: a retrospective cohort study,” Lancet, vol. 361, no. 9370, pp. 1671–1676, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. C. Schaedel, I. De Monestrol, L. Hjelte et al., “Predictors of deterioration of lung function in cystic fibrosis,” Pediatric Pulmonology, vol. 33, no. 6, pp. 483–491, 2002. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Corey, L. Edwards, H. Levison, and M. Knowles, “Longitudinal analysis of pulmonary function decline in patients with cystic fibrosis,” Journal of Pediatrics, vol. 131, no. 6, pp. 809–814, 1997. View at Publisher · View at Google Scholar · View at Scopus
  7. M. H. Zhao, S. J. Jones, and C. M. Lockwood, “Bactericidal/permeability-increasing protein (BPI) is an important antigen for anti-neutrophil cytoplasmic autoantibodies (ANCA) in vasculitis,” Clinical and Experimental Immunology, vol. 99, no. 1, pp. 49–56, 1995. View at Scopus
  8. J. Weiss, P. Elsbach, I. Olsson, and H. Odeberg, “Purification and characterization of a potent bactericidal and membrane active protein from the granules of human polymorphonuclear leukocytes,” Journal of Biological Chemistry, vol. 253, no. 8, pp. 2664–2672, 1978. View at Scopus
  9. P. Elsbach, “The bactericidal/permeability-increasing protein (BPI) in antibacterial host defense,” Journal of Leukocyte Biology, vol. 64, no. 1, pp. 14–18, 1998. View at Scopus
  10. P. Elsbach and J. Weiss, “Role of the bactericidal/permeability-increasing protein in host defence,” Current Opinion in Immunology, vol. 10, no. 1, pp. 45–49, 1998. View at Publisher · View at Google Scholar · View at Scopus
  11. M. H. Zhao, D. R. W. Jayne, L. G. Ardiles, F. Culley, M. E. Hodson, and C. M. Lockwood, “Autoantibodies against bactericidal/permeability-increasing protein in patients with cystic fibrosis,” QJM—Monthly Journal of the Association of Physicians, vol. 89, no. 4, pp. 259–265, 1996. View at Scopus
  12. H. Schultz and J. P. Weiss, “The bactericidal/permeability-increasing protein (BPI) in infection and inflammatory disease,” Clinica Chimica Acta, vol. 384, no. 1-2, pp. 12–23, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. N. M. Iovine, P. Elsbach, and J. Weiss, “An opsonic function of the neutrophil bactericidal/permeability-increasing protein depends on both its N- and C-terminal domains,” Proceedings of the National Academy of Sciences of the United States of America, vol. 94, no. 20, pp. 10973–10978, 1997. View at Scopus
  14. M. P. Stoffel, E. Csernok, C. Herzberg, T. Johnston, S. F. Carroll, and W. L. Gross, “Anti-neutrophil cytoplasmic antibodies (ANCA) directed against bactericidal/permeability increasing protein (BPI): a new seromarker for inflammatory bowel disease and associated disorders,” Clinical and Experimental Immunology, vol. 104, no. 1, pp. 54–59, 1996. View at Scopus
  15. A. Šedivá, J. Bartůňková, I. Kolářová et al., “Antineutrophil cytoplasmic autoantibodies (ANCA) in children with cystic fibrosis,” Journal of Autoimmunity, vol. 11, no. 2, pp. 185–190, 1998. View at Publisher · View at Google Scholar · View at Scopus
  16. R. Mahadeva, A. C. Dunn, R. C. Westerbeek et al., “Anti-neutrophil cytoplasmic antibodies (ANCA) against bactericidal/permeability-increasing protein (BPI) and cystic fibrosis lung disease,” Clinical and Experimental Immunology, vol. 117, no. 3, pp. 561–567, 1999. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Carlsson, L. Eriksson, T. Pressler et al., “Autoantibody response to BPI predict disease severity and outcome in cystic fibrosis,” Journal of Cystic Fibrosis, vol. 6, no. 3, pp. 228–233, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. K. Aanaes, N. Rasmussen, T. Pressler, et al., “Extensive endoscopic image-guided sinus surgery decreases BPI-ANCA in patients with cystic fibrosis,” Scandinavian Journal of Immunology, vol. 76, no. 6, pp. 573–579, 2012.
  19. H. Schultz, “From infection to autoimmunity: a new model for induction of ANCA against the bactericidal/permeability increasing protein (BPI),” Autoimmunity Reviews, vol. 6, no. 4, pp. 223–227, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. L. Dorlöchter, M. Carlsson, E. J. Olafsdottir, O. D. RoØksund, K. Rosendahl, and G. Fluge, “Anti-neutrophil cytoplasmatic antibodies and lung disease in cystic fibrosis,” Journal of Cystic Fibrosis, vol. 3, no. 3, pp. 179–183, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Carlsson, L. Eriksson, I. Erwander, J. Wieslander, and M. Segelmark, “Pseudomonas-induced lung damage in cystic fibrosis correlates to bactericidal-permeability increasing protein (BPI)-autoantibodies,” Clinical and Experimental Rheumatology, vol. 21, no. 6, supplement 32, pp. S95–S100, 2003. View at Scopus
  22. H. Schultz, S. Schinke, K. Mosler, K. Herlyn, A. Schuster, and W. L. Gross, “BPI-ANCA of pediatric cystic fibrosis patients can impair BPI-mediated killing of E. coli DH5α in vitro,” Pediatric Pulmonology, vol. 37, no. 2, pp. 158–164, 2004. View at Publisher · View at Google Scholar · View at Scopus
  23. F. Lachenal, K. Nkana, R. Nove-Josserand, N. Fabien, and I. Durieu, “Prevalence and clinical significance of autoantibodies in adults with cystic fibrosis,” European Respiratory Journal, vol. 34, no. 5, pp. 1079–1085, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. T. A. Douglas, S. Brennan, L. Berry et al., “Value of serology in predicting Pseudomonas aeruginosa infection in young children with cystic fibrosis,” Thorax, vol. 65, no. 11, pp. 985–990, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. “Standardization of spirometry, 1994 update. American Thoracic Society,” American Journal of Respiratory and Critical Care Medicine, vol. 152, no. 3, pp. 1107–1136, 1995.
  26. P. H. Quanjer, G. J. Tammeling, J. E. Cotes, O. F. Pedersen, R. Peslin, and J. C. Yernault, “Lung volumes and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society,” The European Respiratory Journal, vol. 16, pp. 5–40, 1993. View at Scopus
  27. N. Rasmussen, C. Sjolin, B. Isaksson, P. Bygren, and J. Wieslander, “An ELISA for the detection of anti-neutrophil cytoplasm antibodies (ANCA),” Journal of Immunological Methods, vol. 127, no. 1, pp. 139–145, 1990. View at Publisher · View at Google Scholar · View at Scopus
  28. T. W. R. Lee, K. G. Brownlee, S. P. Conway, M. Denton, and J. M. Littlewood, “Evaluation of a new definition for chronic Pseudomonas aeruginosa infection in cystic fibrosis patients,” Journal of Cystic Fibrosis, vol. 2, no. 1, pp. 29–34, 2003. View at Publisher · View at Google Scholar · View at Scopus
  29. M. R. Kosorok, L. Zeng, S. E. H. West et al., “Acceleration of lung disease in children with cystic fibrosis after Pseudomonas aeruginosa acquisition,” Pediatric Pulmonology, vol. 32, no. 4, pp. 277–287, 2001. View at Publisher · View at Google Scholar · View at Scopus
  30. A. M. Jones, M. E. Dodd, J. R. W. Govan et al., “Burkholderia cenocepacia and Burkholderia multivorans: influence on survival in cystic fibrosis,” Thorax, vol. 59, no. 11, pp. 948–951, 2004. View at Publisher · View at Google Scholar · View at Scopus
  31. J. Zirbes and C. E. Milla, “Cystic fibrosis related diabetes,” Paediatric Respiratory Reviews, vol. 10, no. 3, pp. 118–123, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. M. Costa, S. Potvin, I. Hammana et al., “Increased glucose excursion in cystic fibrosis and its association with a worse clinical status,” Journal of Cystic Fibrosis, vol. 6, no. 6, pp. 376–383, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. S. J. King, I. B. Nyulasi, B. J. G. Strauss, T. Kotsimbos, M. Bailey, and J. W. Wilson, “Fat-free mass depletion in cystic fibrosis: associated with lung disease severity but poorly detected by body mass index,” Nutrition, vol. 26, no. 7-8, pp. 753–759, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. F. Ratjen, H. Walter, M. Haug, C. Meisner, H. Grasemann, and G. Döring, “Diagnostic value of serum antibodies in early Pseudomonas aeruginosa infection in cystic fibrosis patients,” Pediatric Pulmonology, vol. 42, no. 3, pp. 249–255, 2007. View at Publisher · View at Google Scholar · View at Scopus
  35. M. Kappler, A. Kraxner, D. Reinhardt, B. Ganster, M. Griese, and T. Lang, “Diagnostic and prognostic value of serum antibodies against Pseudomonas aeruginosa in cystic fibrosis,” Thorax, vol. 61, no. 8, pp. 684–688, 2006. View at Publisher · View at Google Scholar · View at Scopus