Interplay of Polarity Proteins and GTPases in T-Lymphocyte Function

Figure 2

GEFs and polarity proteins are important GTPase regulators. GTPases function as switches in cells, controlling a large variety of pathways. They are tightly regulated by Guanine exchange factors (GEFS), GTPase activating proteins (GAPS) and polarity proteins. The recently discovered that GEF, DOCK8, may also be part of this large network. Evidence has shown that it interacts with Cdc42, an important GTPase in the regulation of cell morphology and motility. DOCK8 may also be a regulator of other GTPases that control different cellular functions important for T-cell function.