Complement Factor C7 Contributes to Lung Immunopathology Caused by Mycobacterium tuberculosis
Figure 2
Lung histopathology of wild-type C57BL/6 and C7 −/− mice after the-challenge with MTB Erdman. (a) C57BL/6 mice demonstrate extensive granulomatous inflammation at 60 days post infection, 100x. (b) High power images of wild-type mice show that infiltrates are largely macrophages, 400x. (c) C7 −/− mice have reduced lung immunopathology at day 60 after the infection, 100x. (d) Abundant areas with clusters of lymphocytes are observed in C7 −/− mice, 400x. (e) Rare multinucleated giant cell in C7 −/− mice, 400x.
