Complement Factor C7 Contributes to Lung Immunopathology Caused by Mycobacterium tuberculosis
Figure 3
Lung expression of proinflammatory mediators TNF-α and IFN-γ in wild-type and C7 −/− mice. Lung cytokine expression of TNF-α, and IFN-γ as measured by quantitative PCR in wild type (solid bars) and C7 −/− (open bars) mice at 60 days post challenge with virulent MTB. Data are expressed as fold change relative to naïve mice after normalization to β-actin. Data are presented as the mean with SD, mice per group, per time point. *, comparisons are made to control mice. There were no significant differences in lung expression of IL-6, IL-12p40, TGF-β, or IL-17 (data not shown).
