- About this Journal ·
- Abstracting and Indexing ·
- Advance Access ·
- Aims and Scope ·
- Annual Issues ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Clinical and Developmental Immunology
Volume 2012 (2012), Article ID 432176, 5 pages
Atrioventricular Conduction Delay in Fetuses Exposed to Anti-SSA/Ro and Anti-SSB/La Antibodies: A Magnetocardiography Study
1Department of Neonatology, University Children's Hospital Tuebingen, 72076 Tuebingen, Germany
2MEG and fMEG Center, University of Tuebingen, 72076 Tuebingen, Germany
3Department of Obstetrics and Gynecology, University Hospital Tuebingen, 72076 Tuebingen, Germany
4Centre for Interdisciplinary Clinical Immunology, Rheumatology and Autoinflammatory Diseases and Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen, 72076 Tuebingen, Germany
Received 1 October 2012; Revised 27 November 2012; Accepted 27 November 2012
Academic Editor: Dimitrios P. Bogdanos
Copyright © 2012 Annette Wacker-Gußmann et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- J. P. Buyon and R. M. Clancy, “Neonatal lupus,” in Dubois' Lupus Erythemathodes, D. J. Wallace and B. H. Hahn, Eds., pp. 1058–1080, Lippincott Williams & Wilkins, Philadelphia, Pa, USA, 7th edition, 2006.
- D. M. Friedman, C. Llanos, P. M. Izmirly et al., “Evaluation of fetuses in a study of intravenous immunoglobulin as preventive therapy for congenital heart block: results of a multicenter, prospective, open-label clinical trial,” Arthritis and Rheumatism, vol. 62, no. 4, pp. 1138–1146, 2010.
- J. P. Buyon, R. Hiebert, J. Copel et al., “Autoimmune-associated congenital heart block: demographics, mortality, morbidity and recurrence rates obtained from a national neonatal lupus registry,” Journal of the American College of Cardiology, vol. 31, no. 7, pp. 1658–1666, 1998.
- P. M. Izmirly, A. Saxena, M. Y. Kim et al., “Maternal and fetal factors associated with mortality and morbidity in a multi-racial/ethnic registry of anti-SSA/Ro-associated cardiac neonatal lupus,” Circulation, vol. 124, no. 18, pp. 1927–1935, 2011.
- H. Eliasson, S. E. Sonesson, G. Sharland et al., “Isolated atrioventricular block in the fetus: a retrospective, multinational, multicenter study of 175 patients,” Circulation, vol. 124, pp. 1919–1926, 2011.
- E. T. Jaeggi, R. M. Hamilton, E. D. Silverman, S. A. Zamora, and L. K. Hornberger, “Outcome of children with fetal, neonatal or childhood diagnosis of isolated congenital atrioventricular block: a single institution's experience of 30 years,” Journal of the American College of Cardiology, vol. 39, no. 1, pp. 130–137, 2002.
- B. F. Cuneo, J. F. Strasburger, A. Niksch, M. Ovadia, and R. T. Wakai, “An expanded phenotype of maternal SSASSB antibody-associated fetal cardiac disease,” Journal of Maternal-Fetal and Neonatal Medicine, vol. 22, no. 3, pp. 233–238, 2009.
- Y. Qu, G. Baroudi, Y. Yue, and M. Boutjdir, “Novel molecular mechanism involving α1D (Cav1.3) L-type calcium channel in autoimmune-associated sinus bradycardia,” Circulation, vol. 111, no. 23, pp. 3034–3041, 2005.
- R. M. Clancy, P. J. Neufing, P. Zheng et al., “Impaired clearance of apoptotic cardiocytes is linked to anti-SSA/Ro and -SSB/La antibodies in the pathogenesis of congenital heart block,” Journal of Clinical Investigation, vol. 116, no. 9, pp. 2413–2422, 2006.
- H. Zhao, B. F. Cuneo, J. F. Strasburger, J. C. Huhta, N. L. Gotteiner, and R. T. Wakai, “Electrophysiological characteristics of fetal atrioventricular block,” Journal of the American College of Cardiology, vol. 51, no. 1, pp. 77–84, 2008.
- J. F. Strasburger and R. T. Wakai, “Fetal cardiac arrhythmia detection and in utero therapy,” Nature Reviews Cardiology, vol. 7, no. 5, pp. 277–290, 2010.
- P. Van Leeuwen, S. Schiermeier, S. Lange et al., “Gender-related changes in magnetocardiographically determined fetal cardiac time intervals in intrauterine growth retardation,” Pediatric Research, vol. 59, no. 6, pp. 820–824, 2006.
- H. Preissl, C. L. Lowery, and H. Eswaran, “Fetal magnetoencephalography: current progress and trends,” Experimental Neurology, vol. 190, no. 1, pp. S28–S36, 2004.
- J. McCubbin, S. E. Robinson, R. Cropp et al., “Optimal reduction of MCG in fetal MEG recordings,” IEEE Transactions on Biomedical Engineering, vol. 53, no. 8, pp. 1720–1724, 2006.
- J. Vrba, S. E. Robinson, J. McCubbin et al., “Fetal MEG redistribution by projection operators,” IEEE Transactions on Biomedical Engineering, vol. 51, no. 7, pp. 1207–1218, 2004.
- S. M. Robinson, T. Wheeler, M. C. Hayes, D. J. P. Barker, and C. Osmond, “Fetal heart rate and intrauterine growth,” British Journal of Obstetrics and Gynaecology, vol. 98, no. 12, pp. 1223–1227, 1991.
- M. K. Park and W. G. Gunteroth, How To Read Pediatric ECG'S, Mosby, St. Louis, Mo, USA, 3rd edition, 1993.
- A. Ambrosi and M. Wahren-Herlenius, “Congenital heart block: evidence for a pathogenic role of maternal autoantibodies,” Arthritis Research & Therapy, vol. 14, no. 2, p. 208, 2012.
- M. Boutjdir, L. Chen, Z. H. Zhang, C. E. Tseng, N. El-Sherif, and J. P. Buyon, “Serum and immunoglobulin G from the mother of a child with congenital heart block induce conduction abnormalities and inhibit L-type calcium channels in a rat heart model,” Pediatric Research, vol. 44, no. 1, pp. 11–19, 1998.
- M. Wahren-Herlenius and S. E. Sonesson, “Specificity and effector mechanisms of autoantibodies in congenital heart block,” Current Opinion in Immunology, vol. 18, no. 6, pp. 690–696, 2006.
- S. E. Sonesson, S. Salomonsson, L. A. Jacobsson, K. Bremme, and M. Wahren-Herlenius, “Signs of first-degree heart block occur in one-third of fetuses of pregnant women with anti-SSA/Ro 52-kd antibodies,” Arthritis and Rheumatism, vol. 50, no. 4, pp. 1253–1261, 2004.