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Clinical and Developmental Immunology
Volume 2012 (2012), Article ID 432176, 5 pages
http://dx.doi.org/10.1155/2012/432176
Research Article

Atrioventricular Conduction Delay in Fetuses Exposed to Anti-SSA/Ro and Anti-SSB/La Antibodies: A Magnetocardiography Study

1Department of Neonatology, University Children's Hospital Tuebingen, 72076 Tuebingen, Germany
2MEG and fMEG Center, University of Tuebingen, 72076 Tuebingen, Germany
3Department of Obstetrics and Gynecology, University Hospital Tuebingen, 72076 Tuebingen, Germany
4Centre for Interdisciplinary Clinical Immunology, Rheumatology and Autoinflammatory Diseases and Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen, 72076 Tuebingen, Germany

Received 1 October 2012; Revised 27 November 2012; Accepted 27 November 2012

Academic Editor: Dimitrios P. Bogdanos

Copyright © 2012 Annette Wacker-Gußmann et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. P. Buyon and R. M. Clancy, “Neonatal lupus,” in Dubois' Lupus Erythemathodes, D. J. Wallace and B. H. Hahn, Eds., pp. 1058–1080, Lippincott Williams & Wilkins, Philadelphia, Pa, USA, 7th edition, 2006.
  2. D. M. Friedman, C. Llanos, P. M. Izmirly et al., “Evaluation of fetuses in a study of intravenous immunoglobulin as preventive therapy for congenital heart block: results of a multicenter, prospective, open-label clinical trial,” Arthritis and Rheumatism, vol. 62, no. 4, pp. 1138–1146, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. J. P. Buyon, R. Hiebert, J. Copel et al., “Autoimmune-associated congenital heart block: demographics, mortality, morbidity and recurrence rates obtained from a national neonatal lupus registry,” Journal of the American College of Cardiology, vol. 31, no. 7, pp. 1658–1666, 1998. View at Publisher · View at Google Scholar · View at Scopus
  4. P. M. Izmirly, A. Saxena, M. Y. Kim et al., “Maternal and fetal factors associated with mortality and morbidity in a multi-racial/ethnic registry of anti-SSA/Ro-associated cardiac neonatal lupus,” Circulation, vol. 124, no. 18, pp. 1927–1935, 2011.
  5. H. Eliasson, S. E. Sonesson, G. Sharland et al., “Isolated atrioventricular block in the fetus: a retrospective, multinational, multicenter study of 175 patients,” Circulation, vol. 124, pp. 1919–1926, 2011.
  6. E. T. Jaeggi, R. M. Hamilton, E. D. Silverman, S. A. Zamora, and L. K. Hornberger, “Outcome of children with fetal, neonatal or childhood diagnosis of isolated congenital atrioventricular block: a single institution's experience of 30 years,” Journal of the American College of Cardiology, vol. 39, no. 1, pp. 130–137, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. B. F. Cuneo, J. F. Strasburger, A. Niksch, M. Ovadia, and R. T. Wakai, “An expanded phenotype of maternal SSASSB antibody-associated fetal cardiac disease,” Journal of Maternal-Fetal and Neonatal Medicine, vol. 22, no. 3, pp. 233–238, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. Y. Qu, G. Baroudi, Y. Yue, and M. Boutjdir, “Novel molecular mechanism involving α1D (Cav1.3) L-type calcium channel in autoimmune-associated sinus bradycardia,” Circulation, vol. 111, no. 23, pp. 3034–3041, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. R. M. Clancy, P. J. Neufing, P. Zheng et al., “Impaired clearance of apoptotic cardiocytes is linked to anti-SSA/Ro and -SSB/La antibodies in the pathogenesis of congenital heart block,” Journal of Clinical Investigation, vol. 116, no. 9, pp. 2413–2422, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. H. Zhao, B. F. Cuneo, J. F. Strasburger, J. C. Huhta, N. L. Gotteiner, and R. T. Wakai, “Electrophysiological characteristics of fetal atrioventricular block,” Journal of the American College of Cardiology, vol. 51, no. 1, pp. 77–84, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. J. F. Strasburger and R. T. Wakai, “Fetal cardiac arrhythmia detection and in utero therapy,” Nature Reviews Cardiology, vol. 7, no. 5, pp. 277–290, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. P. Van Leeuwen, S. Schiermeier, S. Lange et al., “Gender-related changes in magnetocardiographically determined fetal cardiac time intervals in intrauterine growth retardation,” Pediatric Research, vol. 59, no. 6, pp. 820–824, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. H. Preissl, C. L. Lowery, and H. Eswaran, “Fetal magnetoencephalography: current progress and trends,” Experimental Neurology, vol. 190, no. 1, pp. S28–S36, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. J. McCubbin, S. E. Robinson, R. Cropp et al., “Optimal reduction of MCG in fetal MEG recordings,” IEEE Transactions on Biomedical Engineering, vol. 53, no. 8, pp. 1720–1724, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. J. Vrba, S. E. Robinson, J. McCubbin et al., “Fetal MEG redistribution by projection operators,” IEEE Transactions on Biomedical Engineering, vol. 51, no. 7, pp. 1207–1218, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. S. M. Robinson, T. Wheeler, M. C. Hayes, D. J. P. Barker, and C. Osmond, “Fetal heart rate and intrauterine growth,” British Journal of Obstetrics and Gynaecology, vol. 98, no. 12, pp. 1223–1227, 1991. View at Scopus
  17. M. K. Park and W. G. Gunteroth, How To Read Pediatric ECG'S, Mosby, St. Louis, Mo, USA, 3rd edition, 1993.
  18. A. Ambrosi and M. Wahren-Herlenius, “Congenital heart block: evidence for a pathogenic role of maternal autoantibodies,” Arthritis Research & Therapy, vol. 14, no. 2, p. 208, 2012.
  19. M. Boutjdir, L. Chen, Z. H. Zhang, C. E. Tseng, N. El-Sherif, and J. P. Buyon, “Serum and immunoglobulin G from the mother of a child with congenital heart block induce conduction abnormalities and inhibit L-type calcium channels in a rat heart model,” Pediatric Research, vol. 44, no. 1, pp. 11–19, 1998. View at Scopus
  20. M. Wahren-Herlenius and S. E. Sonesson, “Specificity and effector mechanisms of autoantibodies in congenital heart block,” Current Opinion in Immunology, vol. 18, no. 6, pp. 690–696, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. S. E. Sonesson, S. Salomonsson, L. A. Jacobsson, K. Bremme, and M. Wahren-Herlenius, “Signs of first-degree heart block occur in one-third of fetuses of pregnant women with anti-SSA/Ro 52-kd antibodies,” Arthritis and Rheumatism, vol. 50, no. 4, pp. 1253–1261, 2004. View at Publisher · View at Google Scholar · View at Scopus